Names & Taxonomy
- Uniprot ID:
- P51797
- Entry Name:
- CLCN6_HUMAN
- Status:
- reviewed
- Protein Names:
- Chloride transport protein 6 (Chloride channel protein 6) (ClC-6)
- Gene Names:
- CLCN6 KIAA0046
- Gene Names Primary:
- CLCN6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 869
- Sequence:
- MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVEKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRSQSMKSYPSSELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQARLRQHYQTI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endosome membrane
- Intramembrane:
- INTRAMEM 159 166 Helical.
Function
- Function:
- Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.
- Gene Ontology Go:
- endosome membrane
integral component of membrane
lysosomal membrane
antiporter activity
ATP binding
voltage-gated chloride channel activity
cell volume homeostasis
chloride transport
ion transmembrane transport
regulation of anion transmembrane transport
response to mechanical stimulus
signal transduction
transmembrane transport - Gene Ontology Biological Process:
- cell volume homeostasis
chloride transport
ion transmembrane transport
regulation of anion transmembrane transport
response to mechanical stimulus
signal transduction
transmembrane transport - Gene Ontology Molecular Function:
- antiporter activity
ATP binding
voltage-gated chloride channel activity - Gene Ontology Cellular Component:
- endosome membrane
integral component of membrane
lysosomal membrane - Keywords:
- ATP-binding
Alternative splicing
Antiport
CBS domain
Chloride
Complete proteome
Endosome
Glycoprotein
Ion transport
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport