Names & Taxonomy

Uniprot ID:
P51795
Entry Name:
CLCN5_HUMAN
Status:
reviewed
Protein Names:
H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)
Gene Names:
CLCN5 CLCK2
Gene Names Primary:
CLCN5
Organism:
Homo sapiens (Human)

Structure

Length:
746
Sequence:
MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Golgi apparatus membrane
Intramembrane:
INTRAMEM 170 177 Helical.

Function

Function:
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
Gene Ontology Go:
apical part of cell
endosome membrane
Golgi membrane
integral component of plasma membrane
lysosomal membrane
membrane
antiporter activity
ATP binding
chloride channel activity
voltage-gated chloride channel activity
chloride transmembrane transport
excretion
ion transmembrane transport
transmembrane transport
transport
Gene Ontology Biological Process:
chloride transmembrane transport
excretion
ion transmembrane transport
transmembrane transport
transport
Gene Ontology Molecular Function:
antiporter activity
ATP binding
chloride channel activity
voltage-gated chloride channel activity
Gene Ontology Cellular Component:
apical part of cell
endosome membrane
Golgi membrane
integral component of plasma membrane
lysosomal membrane
membrane
Keywords:
3D-structure
ATP-binding
Alternative splicing
Antiport
CBS domain
Cell membrane
Chloride
Complete proteome
Disease mutation
Endosome
Golgi apparatus
Ion transport
Membrane
Nucleotide-binding
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Ubl conjugation

Publication

PubMed ID:
8575751 14702039 15772651 15489334 7874126 12886045 10198195 15489223 25944712 17195847 8559248 9187673 9259268 9062355 9602200 9853249 11136179 15086899 16247550 16822791 16416111 17262170 18025833 19019917 19657328 21305656