Names & Taxonomy
- Uniprot ID:
- P51795
- Entry Name:
- CLCN5_HUMAN
- Status:
- reviewed
- Protein Names:
- H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)
- Gene Names:
- CLCN5 CLCK2
- Gene Names Primary:
- CLCN5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 746
- Sequence:
- MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus membrane
- Intramembrane:
- INTRAMEM 170 177 Helical.
Function
- Function:
- Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
- Gene Ontology Go:
- apical part of cell
endosome membrane
Golgi membrane
integral component of plasma membrane
lysosomal membrane
membrane
antiporter activity
ATP binding
chloride channel activity
voltage-gated chloride channel activity
chloride transmembrane transport
excretion
ion transmembrane transport
transmembrane transport
transport - Gene Ontology Biological Process:
- chloride transmembrane transport
excretion
ion transmembrane transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- antiporter activity
ATP binding
chloride channel activity
voltage-gated chloride channel activity - Gene Ontology Cellular Component:
- apical part of cell
endosome membrane
Golgi membrane
integral component of plasma membrane
lysosomal membrane
membrane - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Antiport
CBS domain
Cell membrane
Chloride
Complete proteome
Disease mutation
Endosome
Golgi apparatus
Ion transport
Membrane
Nucleotide-binding
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Ubl conjugation