Names & Taxonomy
- Uniprot ID:
- P51788
- Entry Name:
- CLCN2_HUMAN
- Status:
- reviewed
- Protein Names:
- Chloride channel protein 2 (ClC-2)
- Gene Names:
- CLCN2
- Gene Names Primary:
- CLCN2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 898
- Sequence:
- MAAAAAEEGMEPRALQYEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSRAAPELLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESAGIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPHSRHGLPREGSPSDSDDKCQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 164 171 Helical.
Function
- Function:
- Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
- Cross Reference Drug Bank:
- DB01046
- Gene Ontology Go:
- chloride channel complex
plasma membrane
voltage-gated chloride channel activity
cell differentiation involved in salivary gland development
ion transmembrane transport
retina development in camera-type eye
transmembrane transport
transport - Gene Ontology Biological Process:
- cell differentiation involved in salivary gland development
ion transmembrane transport
retina development in camera-type eye
transmembrane transport
transport - Gene Ontology Molecular Function:
- voltage-gated chloride channel activity
- Gene Ontology Cellular Component:
- chloride channel complex
plasma membrane - Keywords:
- Acetylation
Alternative splicing
CBS domain
Cell membrane
Chloride
Chloride channel
Complete proteome
Disease mutation
Epilepsy
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel