Names & Taxonomy
- Uniprot ID:
- P51648
- Entry Name:
- AL3A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Fatty aldehyde dehydrogenase (EC 1.2.1.3) (Aldehyde dehydrogenase 10) (Aldehyde dehydrogenase family 3 member A2) (Microsomal aldehyde dehydrogenase)
- Gene Names:
- ALDH3A2 ALDH10 FALDH
- Gene Names Primary:
- ALDH3A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 485
- Sequence:
- MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKAEYY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Function
- Function:
- Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
- Catalytic Activity:
- An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
- Active Site:
- ACT_SITE 207 207
- Gene Ontology Go:
- cytosol
endoplasmic reticulum membrane
extracellular exosome
extrinsic component of endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
mitochondrial inner membrane
nucleus
peroxisome
3-chloroallyl aldehyde dehydrogenase activity
aldehyde dehydrogenase (NAD) activity
aldehyde dehydrogenase activity
long-chain-alcohol oxidase activity
long-chain-aldehyde dehydrogenase activity
medium-chain-aldehyde dehydrogenase activity
cellular aldehyde metabolic process
central nervous system development
epidermis development
formaldehyde metabolic process
oxidation-reduction process
peripheral nervous system development
phytol metabolic process
response to reactive oxygen species
sesquiterpenoid metabolic process
small molecule metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process - Gene Ontology Biological Process:
- cellular aldehyde metabolic process
central nervous system development
epidermis development
formaldehyde metabolic process
oxidation-reduction process
peripheral nervous system development
phytol metabolic process
response to reactive oxygen species
sesquiterpenoid metabolic process
small molecule metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process - Gene Ontology Molecular Function:
- 3-chloroallyl aldehyde dehydrogenase activity
aldehyde dehydrogenase (NAD) activity
aldehyde dehydrogenase activity
long-chain-alcohol oxidase activity
long-chain-aldehyde dehydrogenase activity
medium-chain-aldehyde dehydrogenase activity - Gene Ontology Cellular Component:
- cytosol
endoplasmic reticulum membrane
extracellular exosome
extrinsic component of endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
mitochondrial inner membrane
nucleus
peroxisome - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Endoplasmic reticulum
Ichthyosis
Membrane
Mental retardation
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix