Names & Taxonomy
- Uniprot ID:
- P51580
- Entry Name:
- TPMT_HUMAN
- Status:
- reviewed
- Protein Names:
- Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase)
- Gene Names:
- TPMT
- Gene Names Primary:
- TPMT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 245
- Sequence:
- MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGKSGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIPGTKVFKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRCLEKVDAFEERHKSWGIDCLFEKLYLLTEK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.
- Catalytic Activity:
- S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=5.6 mM for S-adenosyl-L-methionine
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by S-adenosyl-L-homocysteine (SAH).
- Cross Reference Drug Bank:
- DB00993 DB00436 DB01327 DB01033 DB01250 DB01021
- Gene Ontology Go:
- cytosol
extracellular exosome
thiopurine S-methyltransferase activity
methylation
nucleobase-containing compound metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- methylation
nucleobase-containing compound metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- thiopurine S-methyltransferase activity
- Gene Ontology Cellular Component:
- cytosol
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Methyltransferase
Phosphoprotein
Polymorphism
Reference proteome
S-adenosyl-L-methionine
Transferase