Names & Taxonomy
- Uniprot ID:
- P51172
- Entry Name:
- SCNND_HUMAN
- Status:
- reviewed
- Protein Names:
- Amiloride-sensitive sodium channel subunit delta (Delta-NaCH) (Epithelial Na(+) channel subunit delta) (Delta-ENaC) (ENaCD) (Nonvoltage-gated sodium channel 1 subunit delta) (SCNED)
- Gene Names:
- SCNN1D DNACH
- Gene Names Primary:
- SCNN1D
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 638
- Sequence:
- MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
- Cross Reference Drug Bank:
- DB00594 DB00384
- Gene Ontology Go:
- actin cytoskeleton
integral component of membrane
membrane
plasma membrane
ligand-gated sodium channel activity
ion transmembrane transport
response to stimulus
sensory perception of taste
sodium ion transmembrane transport
sodium ion transport
transmembrane transport - Gene Ontology Biological Process:
- ion transmembrane transport
response to stimulus
sensory perception of taste
sodium ion transmembrane transport
sodium ion transport
transmembrane transport - Gene Ontology Molecular Function:
- ligand-gated sodium channel activity
- Gene Ontology Cellular Component:
- actin cytoskeleton
integral component of membrane
membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Ion channel
Ion transport
Membrane
Polymorphism
Reference proteome
Sensory transduction
Sodium
Sodium channel
Sodium transport
Taste
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q8N668