Names & Taxonomy
- Uniprot ID:
- P51160
- Entry Name:
- PDE6C_HUMAN
- Status:
- reviewed
- Protein Names:
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC 3.1.4.35) (cGMP phosphodiesterase 6C)
- Gene Names:
- PDE6C PDEA2
- Gene Names Primary:
- PDE6C
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 858
- Sequence:
- MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Catalytic Activity:
- Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Active Site:
- ACT_SITE 562 562 Proton donor.
- Cross Reference Drug Bank:
- DB00201
- Gene Ontology Go:
- plasma membrane
3',5'-cyclic-GMP phosphodiesterase activity
cGMP binding
metal ion binding
phototransduction, visible light
retinal cone cell development
visual perception - Gene Ontology Biological Process:
- phototransduction, visible light
retinal cone cell development
visual perception - Gene Ontology Molecular Function:
- 3',5'-cyclic-GMP phosphodiesterase activity
cGMP binding
metal ion binding - Gene Ontology Cellular Component:
- plasma membrane
- Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disease mutation
Hydrolase
Lipoprotein
Membrane
Metal-binding
Methylation
Nucleotide-binding
Polymorphism
Prenylation
Reference proteome
Repeat
Sensory transduction
Vision
cGMP
cGMP-binding