Names & Taxonomy
- Uniprot ID:
- P51149
- Entry Name:
- RAB7A_HUMAN
- Status:
- reviewed
- Protein Names:
- Ras-related protein Rab-7a
- Gene Names:
- RAB7A RAB7
- Gene Names Primary:
- RAB7A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 207
- Sequence:
- MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKASAESCSC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasmic vesicle, phagosome membrane
Function
- Function:
- Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
- Gene Ontology Go:
- alveolar lamellar body
autophagosome membrane
extracellular exosome
extrinsic component of lysosome membrane
Golgi apparatus
intracellular membrane-bounded organelle
late endosome
late endosome membrane
lipid particle
lysosomal membrane
lysosome
melanosome membrane
phagocytic vesicle
phagocytic vesicle membrane
pre-autophagosomal structure membrane
terminal bouton
vacuolar membrane
GDP binding
GTP binding
GTPase activity
antigen processing and presentation of exogenous peptide antigen via MHC class II
bone resorption
early endosome to late endosome transport
endocytosis
endosome to lysosome transport
epidermal growth factor catabolic process
lipophagy
phagosome acidification
phagosome maturation
phagosome-lysosome fusion
positive regulation of exosomal secretion
positive regulation of protein catabolic process
positive regulation of viral process
protein targeting to lysosome
protein to membrane docking
protein transport
regulation of autophagosome assembly
retrograde transport, endosome to Golgi
small GTPase mediated signal transduction
viral release from host cell - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class II
bone resorption
early endosome to late endosome transport
endocytosis
endosome to lysosome transport
epidermal growth factor catabolic process
lipophagy
phagosome acidification
phagosome-lysosome fusion
phagosome maturation
positive regulation of exosomal secretion
positive regulation of protein catabolic process
positive regulation of viral process
protein targeting to lysosome
protein to membrane docking
protein transport
regulation of autophagosome assembly
retrograde transport, endosome to Golgi
small GTPase mediated signal transduction
viral release from host cell - Gene Ontology Molecular Function:
- GDP binding
GTPase activity
GTP binding - Gene Ontology Cellular Component:
- alveolar lamellar body
autophagosome membrane
extracellular exosome
extrinsic component of lysosome membrane
Golgi apparatus
intracellular membrane-bounded organelle
late endosome
late endosome membrane
lipid particle
lysosomal membrane
lysosome
melanosome membrane
phagocytic vesicle
phagocytic vesicle membrane
pre-autophagosomal structure membrane
terminal bouton
vacuolar membrane - Keywords:
- 3D-structure
Acetylation
Autophagy
Charcot-Marie-Tooth disease
Complete proteome
Cytoplasmic vesicle
Disease mutation
Endosome
GTP-binding
Lipid degradation
Lipid droplet
Lipid metabolism
Lipoprotein
Lysosome
Membrane
Methylation
Neurodegeneration
Neuropathy
Nucleotide-binding
Phosphoprotein
Prenylation
Protein transport
Reference proteome
Transport - Interacts With:
- Q96NA2