Names & Taxonomy
- Uniprot ID:
- P50747
- Entry Name:
- BPL1_HUMAN
- Status:
- reviewed
- Protein Names:
- Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)]
- Gene Names:
- HLCS
- Gene Names Primary:
- HLCS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 726
- Sequence:
- MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEHVGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESVKFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFHEVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQGGKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSPGRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRRYEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSLRFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMRLLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPFVQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVLPLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNLILPKRR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Mitochondrion.
Function
- Function:
- Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.
- Catalytic Activity:
- ATP + biotin + apo- = AMP + diphosphate + .; ATP + biotin + apo- = AMP + diphosphate + .; ATP + biotin + apo- = AMP + diphosphate + .; ATP + biotin + apo- = AMP + diphosphate + .
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=224 nM for biotin
- Cross Reference Drug Bank:
- DB00121
- Gene Ontology Go:
- chromatin
cytoplasm
cytosol
mitochondrion
nuclear lamina
nuclear matrix
ATP binding
biotin binding
biotin- ligase activity
biotin- ligase activity
biotin- ligase activity
biotin- ligase activity
biotin-protein ligase activity
enzyme binding
biotin metabolic process
cell proliferation
histone biotinylation
histone modification
protein biotinylation
response to biotin
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- biotin metabolic process
cell proliferation
histone biotinylation
histone modification
protein biotinylation
response to biotin
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- ATP binding
biotin- ligase activity
biotin- ligase activity
biotin- ligase activity
biotin- ligase activity
biotin binding
biotin-protein ligase activity
enzyme binding - Gene Ontology Cellular Component:
- chromatin
cytoplasm
cytosol
mitochondrion
nuclear lamina
nuclear matrix - Keywords:
- ATP-binding
Complete proteome
Cytoplasm
Disease mutation
Ligase
Mitochondrion
Multifunctional enzyme
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- O00763; Q9NUX5