Names & Taxonomy

Uniprot ID:
P50747
Entry Name:
BPL1_HUMAN
Status:
reviewed
Protein Names:
Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)]
Gene Names:
HLCS
Gene Names Primary:
HLCS
Organism:
Homo sapiens (Human)

Structure

Length:
726
Sequence:
MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEHVGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESVKFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFHEVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQGGKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSPGRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRRYEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSLRFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMRLLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPFVQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVLPLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNLILPKRR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Mitochondrion.

Function

Function:
Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.
Catalytic Activity:
ATP + biotin + apo- = AMP + diphosphate + .; ATP + biotin + apo- = AMP + diphosphate + .; ATP + biotin + apo- = AMP + diphosphate + .; ATP + biotin + apo- = AMP + diphosphate + .
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=224 nM for biotin
Cross Reference Drug Bank:
DB00121
Gene Ontology Go:
chromatin
cytoplasm
cytosol
mitochondrion
nuclear lamina
nuclear matrix
ATP binding
biotin binding
biotin- ligase activity
biotin- ligase activity
biotin- ligase activity
biotin- ligase activity
biotin-protein ligase activity
enzyme binding
biotin metabolic process
cell proliferation
histone biotinylation
histone modification
protein biotinylation
response to biotin
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Biological Process:
biotin metabolic process
cell proliferation
histone biotinylation
histone modification
protein biotinylation
response to biotin
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Molecular Function:
ATP binding
biotin- ligase activity
biotin- ligase activity
biotin- ligase activity
biotin- ligase activity
biotin binding
biotin-protein ligase activity
enzyme binding
Gene Ontology Cellular Component:
chromatin
cytoplasm
cytosol
mitochondrion
nuclear lamina
nuclear matrix
Keywords:
ATP-binding
Complete proteome
Cytoplasm
Disease mutation
Ligase
Mitochondrion
Multifunctional enzyme
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Interacts With:
O00763; Q9NUX5

Publication

PubMed ID:
7842009 9037601 11735028 14702039 10830953 15489334 9503011 18669648 21269460 24275569 8541348 8817339 9396568 10190325 10590022 12124727 12633764 16134170 16959974 18429047 20095979 25690727