Names & Taxonomy

Uniprot ID:
P50443
Entry Name:
S26A2_HUMAN
Status:
reviewed
Protein Names:
Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2)
Gene Names:
SLC26A2 DTD DTDST
Gene Names Primary:
SLC26A2
Organism:
Homo sapiens (Human)

Structure

Length:
739
Sequence:
MSSESKEQHNVSPRDSAEGNDSYPSGIHLELQRESSTDFKQFETNDQCRPYHRILIERQEKSDTNFKEFVIKKLQKNCQCSPAKAKNMILGFLPVLQWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPVYGLYTSFFASIIYFLLGTSRHISVGIFGVLCLMIGETVDRELQKAGYDNAHSAPSLGMVSNGSTLLNHTSDRICDKSCYAIMVGSTVTFIAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLNLPRTNGVGSLITTWIHVFRNIHKTNLCDLITSLLCLLVLLPTKELNEHFKSKLKAPIPIELVVVVAATLASHFGKLHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTGCHTQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKFRDLPKMWSISRMDTVIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKSSLLGLVEESEVFESVSAYKNLQIKPGIKIFRFVAPLYYINKECFKSALYKQTVNPILIKVAWKKAAKRKIKEKVVTLGGIQDEMSVQLSHDPLELHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAIGIQVLLAQCNPTVRDSLTNGEYCKKEEENLLFYSVYEAMAFAEVSKNQKGVCVPNGLSLSSD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Sulfate transporter. May play a role in endochondral bone formation.
Gene Ontology Go:
extracellular exosome
integral component of plasma membrane
membrane
plasma membrane
anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
3'-phosphoadenosine 5'-phosphosulfate metabolic process
bicarbonate transport
carbohydrate metabolic process
chloride transmembrane transport
glycosaminoglycan metabolic process
ion transport
ossification
oxalate transport
regulation of intracellular pH
regulation of membrane potential
small molecule metabolic process
sulfate transport
transmembrane transport
xenobiotic metabolic process
Gene Ontology Biological Process:
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
3'-phosphoadenosine 5'-phosphosulfate metabolic process
bicarbonate transport
carbohydrate metabolic process
chloride transmembrane transport
glycosaminoglycan metabolic process
ion transport
ossification
oxalate transport
regulation of intracellular pH
regulation of membrane potential
small molecule metabolic process
sulfate transport
transmembrane transport
xenobiotic metabolic process
Gene Ontology Molecular Function:
anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity
Gene Ontology Cellular Component:
extracellular exosome
integral component of plasma membrane
membrane
plasma membrane
Keywords:
Complete proteome
Disease mutation
Dwarfism
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
7923357 14702039 15372022 15489334 17974005 18669648 8528239 8571951 10466420 12966518 21922596