Names & Taxonomy
- Uniprot ID:
- P50406
- Entry Name:
- 5HT6R_HUMAN
- Status:
- reviewed
- Protein Names:
- 5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (Serotonin receptor 6)
- Gene Names:
- HTR6
- Gene Names Primary:
- HTR6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 440
- Sequence:
- MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).
- Cross Reference Drug Bank:
- DB00321 DB00543 DB01238 DB06216 DB00477 DB00363 DB01142 DB01049 DB04946 DB00458 DB00408 DB06148 DB00540 DB00334 DB01224 DB06144 DB00246
- Gene Ontology Go:
- cilium
integral component of plasma membrane
plasma membrane
G-protein coupled serotonin receptor activity
histamine receptor activity
cerebral cortex cell migration
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of TOR signaling
synaptic transmission - Gene Ontology Biological Process:
- cerebral cortex cell migration
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of TOR signaling
synaptic transmission - Gene Ontology Molecular Function:
- G-protein coupled serotonin receptor activity
histamine receptor activity - Gene Ontology Cellular Component:
- cilium
integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Membrane
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P06241