Names & Taxonomy
- Uniprot ID:
- P49788
- Entry Name:
- TIG1_HUMAN
- Status:
- reviewed
- Protein Names:
- Retinoic acid receptor responder protein 1 (Phorbol ester-induced gene 1 protein) (PERG-1) (RAR-responsive protein TIG1) (Tazarotene-induced gene 1 protein)
- Gene Names:
- RARRES1 PEIG1 TIG1
- Gene Names Primary:
- RARRES1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 294
- Sequence:
- MQPRRQRLPAPWSGPRGPRPTAPLLALLLLLAPVAAPAGSGDPDDPGQPQDAGVPRRLLQQAARAALHFFNFRSGSPSALRVLAEVQEGRAWINPKEGCKVHVVFSTERYNPESLLQEGEGRLGKCSARVFFKNQKPRPTINVTCTRLIEKKKRQQEDYLLYKQMKQLKNPLEIVSIPDNHGHIDPSLRLIWDLAFLGSSYVMWEMTTQVSHYYLAQLTSVRQWKTNDDTIDFDYTVLLHELSTQEIIPCRIHLVWYPGKPLKVKYHCQELQTPEEASGTEEGSAVVPTELSNF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.
- Cross Reference Drug Bank:
- DB00755
- Gene Ontology Go:
- extracellular exosome
integral component of membrane
negative regulation of cell proliferation - Gene Ontology Biological Process:
- negative regulation of cell proliferation
- Gene Ontology Cellular Component:
- extracellular exosome
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Membrane
Polymorphism
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix