Names & Taxonomy
- Uniprot ID:
- P49761
- Entry Name:
- CLK3_HUMAN
- Status:
- reviewed
- Protein Names:
- Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
- Gene Names:
- CLK3
- Gene Names Primary:
- CLK3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 638
- Sequence:
- MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Nucleus. Cytoplasm
Function
- Function:
- Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Enzyme Regulation:
- ENZYME REGULATION: Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins.
- Active Site:
- ACT_SITE 431 431 Proton acceptor.
- Gene Ontology Go:
- acrosomal vesicle
intermediate filament cytoskeleton
membrane
nuclear speck
nucleoplasm
nucleus
ATP binding
poly(A) RNA binding
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
protein autophosphorylation
protein phosphorylation
regulation of RNA splicing - Gene Ontology Biological Process:
- protein autophosphorylation
protein phosphorylation
regulation of RNA splicing - Gene Ontology Molecular Function:
- ATP binding
poly(A) RNA binding
protein serine/threonine/tyrosine kinase activity
protein serine/threonine kinase activity
protein tyrosine kinase activity - Gene Ontology Cellular Component:
- acrosomal vesicle
intermediate filament cytoskeleton
membrane
nuclear speck
nucleoplasm
nucleus - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Kinase
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Tyrosine-protein kinase - Interacts With:
- P49760; P17509; P09629; P29728; P38159; P0DJD3; Q15415; Q9BUV0; O00560; P78362; O43463; Q9BSI4; O14978