Names & Taxonomy
- Uniprot ID:
- P49638
- Entry Name:
- TTPA_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-tocopherol transfer protein (Alpha-TTP)
- Gene Names:
- TTPA TPP1
- Gene Names Primary:
- TTPA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 278
- Sequence:
- MAEARSQPSAGPQLNALPDHSPLLQPGLAALRRRAREAGVPLAPLPLTDSFLLRFLRARDFDLDLAWRLLKNYYKWRAECPEISADLHPRSIIGLLKAGYHGVLRSRDPTGSKVLIYRIAHWDPKVFTAYDVFRVSLITSELIVQEVETQRNGIKAIFDLEGWQFSHAFQITPSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSLLQHFPDILPLEYGGEEFSMEDICQEWTNFIMKSEDYLSSISESIQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity).
- Cross Reference Drug Bank:
- DB00163
- Gene Ontology Go:
- cytosol
late endosome
phosphatidylinositol-3,4-bisphosphate binding
phosphatidylinositol-4,5-bisphosphate binding
transporter activity
vitamin E binding
embryonic placenta development
intermembrane transport
intracellular pH reduction
lipid metabolic process
negative regulation of cell death
negative regulation of establishment of blood-brain barrier
response to nutrient
response to pH
response to toxic substance
transport
vitamin E metabolic process
vitamin transport - Gene Ontology Biological Process:
- embryonic placenta development
intermembrane transport
intracellular pH reduction
lipid metabolic process
negative regulation of cell death
negative regulation of establishment of blood-brain barrier
response to nutrient
response to pH
response to toxic substance
transport
vitamin E metabolic process
vitamin transport - Gene Ontology Molecular Function:
- phosphatidylinositol-3,4-bisphosphate binding
phosphatidylinositol-4,5-bisphosphate binding
transporter activity
vitamin E binding - Gene Ontology Cellular Component:
- cytosol
late endosome - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Disease mutation
Lipid-binding
Reference proteome
Transport - Interacts With:
- Q96DZ9