Names & Taxonomy
- Uniprot ID:
- P49591
- Entry Name:
- SYSC_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)
- Gene Names:
- SARS SERS
- Gene Names Primary:
- SARS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 514
- Sequence:
- MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
- Pathway:
- Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.
- Catalytic Activity:
- ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).; ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
- Cross Reference Drug Bank:
- DB00133
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
ATP binding
RNA binding
selenocysteine-tRNA ligase activity
serine-tRNA ligase activity
cellular nitrogen compound metabolic process
gene expression
selenium compound metabolic process
selenocysteine metabolic process
selenocysteinyl-tRNA(Sec) biosynthetic process
seryl-tRNA aminoacylation
small molecule metabolic process
translation
tRNA aminoacylation for protein translation
tRNA processing - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
gene expression
selenium compound metabolic process
selenocysteine metabolic process
selenocysteinyl-tRNA(Sec) biosynthetic process
seryl-tRNA aminoacylation
small molecule metabolic process
translation
tRNA aminoacylation for protein translation
tRNA processing - Gene Ontology Molecular Function:
- ATP binding
RNA binding
selenocysteine-tRNA ligase activity
serine-tRNA ligase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome - Keywords:
- 3D-structure
ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Complete proteome
Cytoplasm
Ligase
Nucleotide-binding
Phosphoprotein
Protein biosynthesis
Reference proteome