Names & Taxonomy
- Uniprot ID:
- P49589
- Entry Name:
- SYCC_HUMAN
- Status:
- reviewed
- Protein Names:
- Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)
- Gene Names:
- CARS
- Gene Names Primary:
- CARS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 748
- Sequence:
- MADSSGQQGKGRRVQPQWSPPAGTQPCRLHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDYFKFDVFYCMNITDIDDKIIKRARQNHLFEQYREKRPEAAQLLEDVQAALKPFSVKLNETTDPDKKQMLERIQHAVQLATEPLEKAVQSRLTGEEVNSCVEVLLEEAKDLLSDWLDSTLGCDVTDNSIFSKLPKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGSVYFDTAKFASSEKHSYGKLVPEAVGDQKALQEGEGDLSISADRLSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDILRAPVDITGQFEKWGEEEAELNKNFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAARKAVRKRPNQALLENIALYLTHMLKIFGAVEEDSSLGFPVGGPGTSLSLEATVMPYLQVLSEFREGVRKIAREQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDRNTLLKEREEKRRVEEEKRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDENGLPTHDMEGKELSKGQAKKLKKLFEAQEKLYKEYLQMAQNGSFQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Catalytic Activity:
- ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Cross Reference Drug Bank:
- DB00151
- Gene Ontology Go:
- cytoplasm
cytosol
ATP binding
cysteine-tRNA ligase activity
metal ion binding
protein homodimerization activity
tRNA binding
cysteinyl-tRNA aminoacylation
gene expression
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- cysteinyl-tRNA aminoacylation
gene expression
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- ATP binding
cysteine-tRNA ligase activity
metal ion binding
protein homodimerization activity
tRNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Chromosomal rearrangement
Complete proteome
Cytoplasm
Ligase
Metal-binding
Nucleotide-binding
Phosphoprotein
Protein biosynthesis
Proto-oncogene
Reference proteome
Zinc