Names & Taxonomy
- Uniprot ID:
- P49368
- Entry Name:
- TCPG_HUMAN
- Status:
- reviewed
- Protein Names:
- T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (hTRiC5)
- Gene Names:
- CCT3 CCTG TRIC5
- Gene Names Primary:
- CCT3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 545
- Sequence:
- MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPVDISDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAPDAGQE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
- Gene Ontology Go:
- cell body
chaperonin-containing T-complex
cytoplasm
cytoskeleton
cytosol
extracellular exosome
microtubule
myelin sheath
plasma membrane
zona pellucida receptor complex
ATP binding
poly(A) RNA binding
protein binding involved in protein folding
unfolded protein binding
'de novo' posttranslational protein folding
binding of sperm to zona pellucida
cellular protein metabolic process
pore complex assembly
positive regulation of protein localization to Cajal body
positive regulation of telomerase RNA localization to Cajal body
positive regulation of telomere maintenance via telomerase
protein folding
protein stabilization
toxin transport - Gene Ontology Biological Process:
- 'de novo' posttranslational protein folding
binding of sperm to zona pellucida
cellular protein metabolic process
pore complex assembly
positive regulation of protein localization to Cajal body
positive regulation of telomerase RNA localization to Cajal body
positive regulation of telomere maintenance via telomerase
protein folding
protein stabilization
toxin transport - Gene Ontology Molecular Function:
- ATP binding
poly(A) RNA binding
protein binding involved in protein folding
unfolded protein binding - Gene Ontology Cellular Component:
- cell body
chaperonin-containing T-complex
cytoplasm
cytoskeleton
cytosol
extracellular exosome
microtubule
myelin sheath
plasma membrane
zona pellucida receptor complex - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Chaperone
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- Q8TD10; P04049