Names & Taxonomy

Uniprot ID:
P49281
Entry Name:
NRAM2_HUMAN
Status:
reviewed
Protein Names:
Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2)
Gene Names:
SLC11A2 DCT1 DMT1 NRAMP2 OK/SW-cl.20
Gene Names Orf:
OK/SW-cl.20
Gene Names Primary:
SLC11A2
Organism:
Homo sapiens (Human)

Structure

Length:
568
Sequence:
MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTCHLGLTAQPELYLLNTMDADSLVSR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 2: Cell membrane

Function

Function:
Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.
Gene Ontology Go:
apical part of cell
apical plasma membrane
basal part of cell
brush border membrane
cell surface
cytoplasm
cytoplasmic vesicle
early endosome
integral component of plasma membrane
late endosome
late endosome membrane
lysosomal membrane
lysosome
membrane
mitochondrial outer membrane
nucleus
paraferritin complex
perinuclear region of cytoplasm
plasma membrane
recycling endosome
trans-Golgi network
vacuole
cadmium ion binding
cadmium ion transmembrane transporter activity
cobalt ion transmembrane transporter activity
copper ion transmembrane transporter activity
ferrous iron transmembrane transporter activity
ferrous iron uptake transmembrane transporter activity
hydrogen ion transmembrane transporter activity
inorganic cation transmembrane transporter activity
lead ion transmembrane transporter activity
manganese ion transmembrane transporter activity
nickel cation transmembrane transporter activity
solute:proton symporter activity
transferrin transmembrane transporter activity
transition metal ion transmembrane transporter activity
vanadium ion transmembrane transporter activity
zinc ion transmembrane transporter activity
activation of cysteine-type endopeptidase activity involved in apoptotic process
cadmium ion transmembrane transport
cation transmembrane transport
cellular iron ion homeostasis
cellular response to oxidative stress
cobalt ion transport
copper ion transmembrane transport
copper ion transport
dendrite morphogenesis
detection of oxygen
erythrocyte development
ferrous iron import
ferrous iron transmembrane transport
ferrous iron transport
heme biosynthetic process
lead ion transport
learning or memory
manganese ion transmembrane transport
manganese ion transport
multicellular organismal iron ion homeostasis
nickel cation transmembrane transport
nickel cation transport
response to hypoxia
response to iron ion
transferrin transport
transmembrane transport
vanadium ion transport
zinc II ion transmembrane transport
Gene Ontology Biological Process:
activation of cysteine-type endopeptidase activity involved in apoptotic process
cadmium ion transmembrane transport
cation transmembrane transport
cellular iron ion homeostasis
cellular response to oxidative stress
cobalt ion transport
copper ion transmembrane transport
copper ion transport
dendrite morphogenesis
detection of oxygen
erythrocyte development
ferrous iron import
ferrous iron transmembrane transport
ferrous iron transport
heme biosynthetic process
lead ion transport
learning or memory
manganese ion transmembrane transport
manganese ion transport
multicellular organismal iron ion homeostasis
nickel cation transmembrane transport
nickel cation transport
response to hypoxia
response to iron ion
transferrin transport
transmembrane transport
vanadium ion transport
zinc II ion transmembrane transport
Gene Ontology Molecular Function:
cadmium ion binding
cadmium ion transmembrane transporter activity
cobalt ion transmembrane transporter activity
copper ion transmembrane transporter activity
ferrous iron transmembrane transporter activity
ferrous iron uptake transmembrane transporter activity
hydrogen ion transmembrane transporter activity
inorganic cation transmembrane transporter activity
lead ion transmembrane transporter activity
manganese ion transmembrane transporter activity
nickel cation transmembrane transporter activity
solute:proton symporter activity
transferrin transmembrane transporter activity
transition metal ion transmembrane transporter activity
vanadium ion transmembrane transporter activity
zinc ion transmembrane transporter activity
Gene Ontology Cellular Component:
apical part of cell
apical plasma membrane
basal part of cell
brush border membrane
cell surface
cytoplasm
cytoplasmic vesicle
early endosome
integral component of plasma membrane
late endosome
late endosome membrane
lysosomal membrane
lysosome
membrane
mitochondrial outer membrane
nucleus
paraferritin complex
perinuclear region of cytoplasm
plasma membrane
recycling endosome
trans-Golgi network
vacuole
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Endosome
Glycoprotein
Ion transport
Iron
Iron transport
Membrane
Mitochondrion
Mitochondrion outer membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport
Ubl conjugation
Interacts With:
P00403

Publication

PubMed ID:
9464519 9790986 9642100 12209011 14702039 16541075 15489334 7613023 12475959 17109629 17293870 18776082 19706893 25491917 24448823 25326704 15459009 16160008 16439678 16959974