Names & Taxonomy
- Uniprot ID:
- P49279
- Entry Name:
- NRAM1_HUMAN
- Status:
- reviewed
- Protein Names:
- Natural resistance-associated macrophage protein 1 (NRAMP 1) (Solute carrier family 11 member 1)
- Gene Names:
- SLC11A1 LSH NRAMP NRAMP1
- Gene Names Primary:
- SLC11A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 550
- Sequence:
- MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIPIPDTKPGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNATVAVDIYQGGVILGCLFGPAALYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALLAAAYLGLSTYLVWTCCLAHGATFLAHSSHHHFLYGLLEEDQKGETSG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
- Gene Ontology Go:
- cell outer membrane
integral component of plasma membrane
late endosome
late endosome membrane
lysosome
phagocytic vesicle membrane
plasma membrane
tertiary granule membrane
manganese ion transmembrane transporter activity
metal ion:proton antiporter activity
protein homodimerization activity
transition metal ion transmembrane transporter activity
activation of protein kinase activity
antigen processing and presentation of peptide antigen
cadmium ion transmembrane transport
cell redox homeostasis
cellular cadmium ion homeostasis
cellular iron ion homeostasis
defense response to bacterium
defense response to Gram-negative bacterium
defense response to protozoan
divalent metal ion export
inflammatory response
interleukin-2 production
interleukin-3 production
iron ion homeostasis
iron ion transport
L-arginine import
macrophage activation
manganese ion transport
MHC class II biosynthetic process
mRNA stabilization
multicellular organismal iron ion homeostasis
negative regulation of cytokine production
nitrite transport
phagocytosis
positive regulation of cytokine production
positive regulation of dendritic cell antigen processing and presentation
positive regulation of gene expression
positive regulation of interferon-gamma production
positive regulation of phagocytosis
positive regulation of T-helper 1 type immune response
positive regulation of transcription from RNA polymerase II promoter
protein import into nucleus, translocation
respiratory burst
response to bacterium
response to interferon-gamma
response to lipopolysaccharide
T cell cytokine production
T cell proliferation involved in immune response
transmembrane transport
vacuolar acidification
wound healing - Gene Ontology Biological Process:
- activation of protein kinase activity
antigen processing and presentation of peptide antigen
cadmium ion transmembrane transport
cell redox homeostasis
cellular cadmium ion homeostasis
cellular iron ion homeostasis
defense response to bacterium
defense response to Gram-negative bacterium
defense response to protozoan
divalent metal ion export
inflammatory response
interleukin-2 production
interleukin-3 production
iron ion homeostasis
iron ion transport
L-arginine import
macrophage activation
manganese ion transport
MHC class II biosynthetic process
mRNA stabilization
multicellular organismal iron ion homeostasis
negative regulation of cytokine production
nitrite transport
phagocytosis
positive regulation of cytokine production
positive regulation of dendritic cell antigen processing and presentation
positive regulation of gene expression
positive regulation of interferon-gamma production
positive regulation of phagocytosis
positive regulation of T-helper 1 type immune response
positive regulation of transcription from RNA polymerase II promoter
protein import into nucleus, translocation
respiratory burst
response to bacterium
response to interferon-gamma
response to lipopolysaccharide
T cell cytokine production
T cell proliferation involved in immune response
transmembrane transport
vacuolar acidification
wound healing - Gene Ontology Molecular Function:
- manganese ion transmembrane transporter activity
metal ion:proton antiporter activity
protein homodimerization activity
transition metal ion transmembrane transporter activity - Gene Ontology Cellular Component:
- cell outer membrane
integral component of plasma membrane
late endosome
late endosome membrane
lysosome
phagocytic vesicle membrane
plasma membrane
tertiary granule membrane - Keywords:
- Alternative splicing
Complete proteome
Glycoprotein
Ion transport
Iron
Iron transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport