Names & Taxonomy
- Uniprot ID:
- P48995
- Entry Name:
- TRPC1_HUMAN
- Status:
- reviewed
- Protein Names:
- Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1)
- Gene Names:
- TRPC1 TRP1
- Gene Names Primary:
- TRPC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 793
- Sequence:
- MMAALYPSTDLSGASSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENENLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
receptor complex
calcium channel activity
cation channel activity
inositol 1,4,5 trisphosphate binding
ion channel binding
store-operated calcium channel activity
axon guidance
calcium ion transmembrane transport
calcium ion transport
cardiac conduction
cellular response to hypoxia
ion transmembrane transport
manganese ion transport
melanin biosynthetic process
positive regulation of release of sequestered calcium ion into cytosol
regulation of cardiac conduction
regulation of cytosolic calcium ion concentration
response to calcium ion
transmembrane transport - Gene Ontology Biological Process:
- axon guidance
calcium ion transmembrane transport
calcium ion transport
cardiac conduction
cellular response to hypoxia
ion transmembrane transport
manganese ion transport
melanin biosynthetic process
positive regulation of release of sequestered calcium ion into cytosol
regulation of cardiac conduction
regulation of cytosolic calcium ion concentration
response to calcium ion
transmembrane transport - Gene Ontology Molecular Function:
- calcium channel activity
cation channel activity
inositol 1,4,5 trisphosphate binding
ion channel binding
store-operated calcium channel activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane
receptor complex - Keywords:
- ANK repeat
Alternative splicing
Calcium
Calcium channel
Calcium transport
Complete proteome
Ion channel
Ion transport
Membrane
Phosphoprotein
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q13563