Names & Taxonomy
- Uniprot ID:
- P48735
- Entry Name:
- IDHP_HUMAN
- Status:
- reviewed
- Protein Names:
- Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)
- Gene Names:
- IDH2
- Gene Names Primary:
- IDH2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 452
- Sequence:
- MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
- Catalytic Activity:
- Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Gene Ontology Go:
- cytosol
extracellular exosome
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
peroxisome
isocitrate dehydrogenase (NADP+) activity
magnesium ion binding
NAD binding
2-oxoglutarate metabolic process
carbohydrate metabolic process
cellular metabolic process
glyoxylate cycle
isocitrate metabolic process
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Biological Process:
- 2-oxoglutarate metabolic process
carbohydrate metabolic process
cellular metabolic process
glyoxylate cycle
isocitrate metabolic process
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- isocitrate dehydrogenase (NADP+) activity
magnesium ion binding
NAD binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
peroxisome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Glyoxylate bypass
Magnesium
Manganese
Metal-binding
Mitochondrion
NADP
Oxidoreductase
Reference proteome
Transit peptide
Tricarboxylic acid cycle