Names & Taxonomy

Uniprot ID:
P48728
Entry Name:
GCST_HUMAN
Status:
reviewed
Protein Names:
Aminomethyltransferase, mitochondrial (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT)
Gene Names:
AMT GCST
Gene Names Primary:
AMT
Organism:
Homo sapiens (Human)

Structure

Length:
403
Sequence:
MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALLALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGAVHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion

Function

Function:
The glycine cleavage system catalyzes the degradation of glycine.
Catalytic Activity:
-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = -dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3).
Cross Reference Drug Bank:
DB00116
Gene Ontology Go:
mitochondrial matrix
mitochondrion
aminomethyltransferase activity
transaminase activity
cellular nitrogen compound metabolic process
glycine catabolic process
glyoxylate metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
cellular nitrogen compound metabolic process
glycine catabolic process
glyoxylate metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
aminomethyltransferase activity
transaminase activity
Gene Ontology Cellular Component:
mitochondrial matrix
mitochondrion
Keywords:
3D-structure
Alternative splicing
Aminotransferase
Complete proteome
Disease mutation
Mitochondrion
Reference proteome
Transferase
Transit peptide

Publication

PubMed ID:
7916605 8188235 14702039 16641997 15489334 24275569 16051266 8005589 9600239 9621520 10873393 11286506 26371980