Names & Taxonomy
- Uniprot ID:
- P48637
- Entry Name:
- GSHB_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase)
- Gene Names:
- GSS
- Gene Names Primary:
- GSS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 474
- Sequence:
- MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKILSNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLARNIHVIRRTFEDISEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQYSLQNWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGMLEMLLPGQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKIEPEPFENCLLRPGSPARVVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV
- Proteomes:
- UP000005640
Function
- Pathway:
- Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.
- Catalytic Activity:
- ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cross Reference Drug Bank:
- DB06151 DB00143 DB00145 DB00151
- Gene Ontology Go:
- cytosol
extracellular exosome
ATP binding
glutathione binding
glutathione synthase activity
glycine binding
magnesium ion binding
protein homodimerization activity
aging
cellular amino acid metabolic process
glutathione biosynthetic process
glutathione derivative biosynthetic process
nervous system development
response to amino acid
response to cadmium ion
response to nutrient levels
response to oxidative stress
response to tumor necrosis factor
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- aging
cellular amino acid metabolic process
glutathione biosynthetic process
glutathione derivative biosynthetic process
nervous system development
response to amino acid
response to cadmium ion
response to nutrient levels
response to oxidative stress
response to tumor necrosis factor
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- ATP binding
glutathione binding
glutathione synthase activity
glycine binding
magnesium ion binding
protein homodimerization activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Glutathione biosynthesis
Hereditary hemolytic anemia
Ligase
Magnesium
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- P54274