Names & Taxonomy
- Uniprot ID:
- P48552
- Entry Name:
- NRIP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140)
- Gene Names:
- NRIP1
- Gene Names Primary:
- NRIP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1158
- Sequence:
- MTHGEELGSDVHQDSIVLTYLEGLLMHQAAGGSGTAVDKKSAGHNEEDQNFNISGSAFPTCQSNGPVLNTHTYQGSGMLHLKKARLLQSSEDWNAAKRKRLSDSIMNLNVKKEALLAGMVDSVPKGKQDSTLLASLLQSFSSRLQTVALSQQIRQSLKEQGYALSHDSLKVEKDLRCYGVASSHLKTLLKKSKVKDQKPDTNLPDVTKNLIRDRFAESPHHVGQSGTKVMSEPLSCAARLQAVASMVEKRASPATSPKPSVACSQLALLLSSEAHLQQYSREHALKTQNANQAASERLAAMARLQENGQKDVGSYQLPKGMSSHLNGQARTSSSKLMASKSSATVFQNPMGIIPSSPKNAGYKNSLERNNIKQAANNSLLLHLLKSQTIPKPMNGHSHSERGSIFEESSTPTTIDEYSDNNPSFTDDSSGDESSYSNCVPIDLSCKHRTEKSESDQPVSLDNFTQSLLNTWDPKVPDVDIKEDQDTSKNSKLNSHQKVTLLQLLLGHKNEENVEKNTSPQGVHNDVSKFNTQNYARTSVIESPSTNRTTPVSTPPLLTSSKAGSPINLSQHSLVIKWNSPPYVCSTQSEKLTNTASNHSMDLTKSKDPPGEKPAQNEGAQNSATFSASKLLQNLAQCGMQSSMSVEEQRPSKQLLTGNTDKPIGMIDRLNSPLLSNKTNAVEENKAFSSQPTGPEPGLSGSEIENLLERRTVLQLLLGNPNKGKSEKKEKTPLRDESTQEHSERALSEQILMVKIKSEPCDDLQIPNTNVHLSHDAKSAPFLGMAPAVQRSAPALPVSEDFKSEPVSPQDFSFSKNGLLSRLLRQNQDSYLADDSDRSHRNNEMALLESKNLCMVPKKRKLYTEPLENPFKKMKNNIVDAANNHSAPEVLYGSLLNQEELKFSRNDLEFKYPAGHGSASESEHRSWARESKSFNVLKQLLLSENCVRDLSPHRSNSVADSKKKGHKNNVTNSKPEFSISSLNGLMYSSTQPSSCMDNRTFSYPGVVKTPVSPTFPEHLGCAGSRPESGLLNGCSMPSEKGPIKWVITDAEKNEYEKDSPRLTKTNPILYYMLQKGGNSVTSRETQDKDIWREASSAESVSQVTAKEELLPTAETKASFFNLRSPYNSHMGNNASRPHSANGEVYGLLGSVLTIKKESE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.
- Gene Ontology Go:
- cell junction
histone deacetylase complex
nuclear chromatin
nuclear speck
nucleolus
nucleoplasm
nucleus
androgen receptor binding
core promoter sequence-specific DNA binding
estrogen receptor binding
glucocorticoid receptor binding
nuclear hormone receptor binding
transcription coactivator activity
transcription corepressor activity
androgen receptor signaling pathway
cellular response to estradiol stimulus
circadian regulation of gene expression
circadian rhythm
lipid storage
negative regulation of transcription from RNA polymerase II promoter
ovarian follicle rupture
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
transcription, DNA-templated - Gene Ontology Biological Process:
- androgen receptor signaling pathway
cellular response to estradiol stimulus
circadian regulation of gene expression
circadian rhythm
lipid storage
negative regulation of transcription from RNA polymerase II promoter
ovarian follicle rupture
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated - Gene Ontology Molecular Function:
- androgen receptor binding
core promoter sequence-specific DNA binding
estrogen receptor binding
glucocorticoid receptor binding
nuclear hormone receptor binding
transcription coactivator activity
transcription corepressor activity - Gene Ontology Cellular Component:
- cell junction
histone deacetylase complex
nuclear chromatin
nuclear speck
nucleolus
nucleoplasm
nucleus - Keywords:
- 3D-structure
Acetylation
Activator
Biological rhythms
Complete proteome
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transcription
Transcription regulation
Ubl conjugation - Interacts With:
- O15145; Q8NHQ1; P26358; Q13642; O15379; O95751; Q99873; P10276; P10276-2; Q8N895