Names & Taxonomy

Uniprot ID:
P48547
Entry Name:
KCNC1_HUMAN
Status:
reviewed
Protein Names:
Potassium voltage-gated channel subfamily C member 1 (NGK2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)
Gene Names:
KCNC1
Gene Names Primary:
KCNC1
Organism:
Homo sapiens (Human)

Structure

Length:
511
Sequence:
MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRAGRKPLRGMSI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
Cross Reference Drug Bank:
DB06637
Gene Ontology Go:
cell surface
dendrite
neuron projection membrane
neuronal cell body membrane
plasma membrane
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
voltage-gated potassium channel activity
cellular response to drug
cerebellum development
globus pallidus development
positive regulation of potassium ion transmembrane transport
potassium ion transmembrane transport
potassium ion transport
protein homooligomerization
protein tetramerization
response to amine
response to auditory stimulus
response to fibroblast growth factor
response to light intensity
response to nerve growth factor
response to potassium ion
response to toxic substance
synaptic transmission
Gene Ontology Biological Process:
cellular response to drug
cerebellum development
globus pallidus development
positive regulation of potassium ion transmembrane transport
potassium ion transmembrane transport
potassium ion transport
protein homooligomerization
protein tetramerization
response to amine
response to auditory stimulus
response to fibroblast growth factor
response to light intensity
response to nerve growth factor
response to potassium ion
response to toxic substance
synaptic transmission
Gene Ontology Molecular Function:
delayed rectifier potassium channel activity
voltage-gated potassium channel activity
Gene Ontology Cellular Component:
cell surface
dendrite
neuronal cell body membrane
neuron projection membrane
plasma membrane
voltage-gated potassium channel complex
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Epilepsy
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

Publication

PubMed ID:
8449507 16554811 1400413 23734863 25401298