Names & Taxonomy

Uniprot ID:
P48507
Entry Name:
GSH0_HUMAN
Status:
reviewed
Protein Names:
Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit)
Gene Names:
GCLM GLCLR
Gene Names Primary:
GCLM
Organism:
Homo sapiens (Human)

Structure

Length:
274
Sequence:
MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINPDLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS
Proteomes:
UP000005640

Function

Pathway:
Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.
Cross Reference Drug Bank:
DB00151
Gene Ontology Go:
cytosol
glutamate-cysteine ligase complex
enzyme regulator activity
glutamate-cysteine ligase activity
glutamate-cysteine ligase catalytic subunit binding
apoptotic mitochondrial changes
cellular nitrogen compound metabolic process
cysteine metabolic process
glutamate metabolic process
glutathione biosynthetic process
glutathione derivative biosynthetic process
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of neuron apoptotic process
positive regulation of glutamate-cysteine ligase activity
regulation of blood vessel size
regulation of mitochondrial depolarization
response to drug
response to nitrosative stress
response to oxidative stress
small molecule metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
apoptotic mitochondrial changes
cellular nitrogen compound metabolic process
cysteine metabolic process
glutamate metabolic process
glutathione biosynthetic process
glutathione derivative biosynthetic process
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of neuron apoptotic process
positive regulation of glutamate-cysteine ligase activity
regulation of blood vessel size
regulation of mitochondrial depolarization
response to drug
response to nitrosative stress
response to oxidative stress
small molecule metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
enzyme regulator activity
glutamate-cysteine ligase activity
glutamate-cysteine ligase catalytic subunit binding
Gene Ontology Cellular Component:
cytosol
glutamate-cysteine ligase complex
Keywords:
Acetylation
Alternative splicing
Complete proteome
Glutathione biosynthesis
Polymorphism
Reference proteome

Publication

PubMed ID:
7826375 14702039 16710414 15489334 19608861 21269460