Names & Taxonomy
- Uniprot ID:
- P48507
- Entry Name:
- GSH0_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit)
- Gene Names:
- GCLM GLCLR
- Gene Names Primary:
- GCLM
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 274
- Sequence:
- MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINPDLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS
- Proteomes:
- UP000005640
Function
- Pathway:
- Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.
- Cross Reference Drug Bank:
- DB00151
- Gene Ontology Go:
- cytosol
glutamate-cysteine ligase complex
enzyme regulator activity
glutamate-cysteine ligase activity
glutamate-cysteine ligase catalytic subunit binding
apoptotic mitochondrial changes
cellular nitrogen compound metabolic process
cysteine metabolic process
glutamate metabolic process
glutathione biosynthetic process
glutathione derivative biosynthetic process
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of neuron apoptotic process
positive regulation of glutamate-cysteine ligase activity
regulation of blood vessel size
regulation of mitochondrial depolarization
response to drug
response to nitrosative stress
response to oxidative stress
small molecule metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- apoptotic mitochondrial changes
cellular nitrogen compound metabolic process
cysteine metabolic process
glutamate metabolic process
glutathione biosynthetic process
glutathione derivative biosynthetic process
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of neuron apoptotic process
positive regulation of glutamate-cysteine ligase activity
regulation of blood vessel size
regulation of mitochondrial depolarization
response to drug
response to nitrosative stress
response to oxidative stress
small molecule metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- enzyme regulator activity
glutamate-cysteine ligase activity
glutamate-cysteine ligase catalytic subunit binding - Gene Ontology Cellular Component:
- cytosol
glutamate-cysteine ligase complex - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Glutathione biosynthesis
Polymorphism
Reference proteome