Names & Taxonomy

Uniprot ID:
P48169
Entry Name:
GBRA4_HUMAN
Status:
reviewed
Protein Names:
Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4)
Gene Names:
GABRA4
Gene Names Primary:
GABRA4
Organism:
Homo sapiens (Human)

Structure

Length:
554
Sequence:
MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKSESLM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Function

Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Cross Reference Drug Bank:
DB00659 DB00404 DB01351 DB00543 DB01352 DB01558 DB00237 DB00241 DB01353 DB00475 DB00349 DB01068 DB00628 DB01189 DB00829 DB00228 DB01049 DB01215 DB00402 DB00898 DB00189 DB00292 DB01205 DB01544 DB00690 DB01437 DB00801 DB01159 DB01354 DB01355 DB00753 DB00186 DB00371 DB01028 DB00849 DB01107 DB00683 DB01595 DB00334 DB00842 DB00312 DB01588 DB00794 DB00818 DB01589 DB00418 DB01236 DB00306 DB00231 DB00599 DB00273 DB00897
Gene Ontology Go:
cell junction
chloride channel complex
GABA-A receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane
benzodiazepine receptor activity
chloride channel activity
extracellular ligand-gated ion channel activity
GABA-A receptor activity
central nervous system development
chemical synaptic transmission, postsynaptic
gamma-aminobutyric acid signaling pathway
ion transmembrane transport
regulation of response to drug
synaptic transmission
transmembrane transport
transport
Gene Ontology Biological Process:
central nervous system development
chemical synaptic transmission, postsynaptic
gamma-aminobutyric acid signaling pathway
ion transmembrane transport
regulation of response to drug
synaptic transmission
transmembrane transport
transport
Gene Ontology Molecular Function:
benzodiazepine receptor activity
chloride channel activity
extracellular ligand-gated ion channel activity
GABA-A receptor activity
Gene Ontology Cellular Component:
cell junction
chloride channel complex
GABA-A receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane
Keywords:
Cell junction
Cell membrane
Chloride
Chloride channel
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8719416 14702039 15815621 15489334 7607683 16959974