Names & Taxonomy

Uniprot ID:
P48167
Entry Name:
GLRB_HUMAN
Status:
reviewed
Protein Names:
Glycine receptor subunit beta (Glycine receptor 58 kDa subunit)
Gene Names:
GLRB
Gene Names Primary:
GLRB
Organism:
Homo sapiens (Human)

Structure

Length:
497
Sequence:
MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane

Function

Function:
Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).
Cross Reference Drug Bank:
DB00228 DB00145 DB00431
Gene Ontology Go:
cell junction
cytoplasm
dendrite
glycine-gated chloride channel complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane
drug binding
extracellular-glycine-gated chloride channel activity
extracellular-glycine-gated ion channel activity
glycine binding
acrosome reaction
adult walking behavior
chloride transmembrane transport
gamma-aminobutyric acid receptor clustering
ion transmembrane transport
ion transport
nervous system development
neuropeptide signaling pathway
protein heterooligomerization
regulation of membrane potential
response to amino acid
righting reflex
startle response
synaptic transmission
synaptic transmission, glycinergic
transmembrane transport
visual perception
Gene Ontology Biological Process:
acrosome reaction
adult walking behavior
chloride transmembrane transport
gamma-aminobutyric acid receptor clustering
ion transmembrane transport
ion transport
nervous system development
neuropeptide signaling pathway
protein heterooligomerization
regulation of membrane potential
response to amino acid
righting reflex
startle response
synaptic transmission
synaptic transmission, glycinergic
transmembrane transport
visual perception
Gene Ontology Molecular Function:
drug binding
extracellular-glycine-gated chloride channel activity
extracellular-glycine-gated ion channel activity
glycine binding
Gene Ontology Cellular Component:
cell junction
cytoplasm
dendrite
glycine-gated chloride channel complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane
Keywords:
Alternative splicing
Cell junction
Cell membrane
Cell projection
Chloride
Chloride channel
Complete proteome
Cytoplasm
Disease mutation
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8717357 9676428 15028279 14702039 15815621 15489334 14551753 12684523 15302677 16144831 22715885 22973015 26613940 25445488 11929858 21391991 23238346