Names & Taxonomy
- Uniprot ID:
- P48058
- Entry Name:
- GRIA4_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4)
- Gene Names:
- GRIA4 GLUR4
- Gene Names Primary:
- GRIA4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 902
- Sequence:
- MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASDLP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression.
- Intramembrane:
- INTRAMEM 593 608 Helical; Pore-forming.
Function
- Function:
- Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
- Cross Reference Drug Bank:
- DB00898
- Gene Ontology Go:
- AMPA glutamate receptor complex
cell junction
dendrite
endocytic vesicle membrane
extracellular vesicle
neuronal cell body
plasma membrane
postsynaptic membrane
terminal bouton
AMPA glutamate receptor activity
extracellular-glutamate-gated ion channel activity
ionotropic glutamate receptor activity
glutamate receptor signaling pathway
response to fungicide
synaptic transmission
transport - Gene Ontology Biological Process:
- glutamate receptor signaling pathway
response to fungicide
synaptic transmission
transport - Gene Ontology Molecular Function:
- AMPA glutamate receptor activity
extracellular-glutamate-gated ion channel activity
ionotropic glutamate receptor activity - Gene Ontology Cellular Component:
- AMPA glutamate receptor complex
cell junction
dendrite
endocytic vesicle membrane
extracellular vesicle
neuronal cell body
plasma membrane
postsynaptic membrane
terminal bouton - Keywords:
- Alternative splicing
Cell junction
Cell membrane
Cell projection
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport