Names & Taxonomy
- Uniprot ID:
- P48051
- Entry Name:
- KCNJ6_HUMAN
- Status:
- reviewed
- Protein Names:
- G protein-activated inward rectifier potassium channel 2 (GIRK-2) (BIR1) (Inward rectifier K(+) channel Kir3.2) (KATP-2) (Potassium channel, inwardly rectifying subfamily J member 6)
- Gene Names:
- KCNJ6 GIRK2 KATP2 KCNJ7
- Gene Names Primary:
- KCNJ6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 423
- Sequence:
- MAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKELAELASRAELPLSWSVSSKLNQHAELETEEEEKNLEEQTERNGDVANLENESKV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
- Intramembrane:
- INTRAMEM 139 150 Helical; Pore-forming; Name=H5.
Function
- Function:
- This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
- Cross Reference Drug Bank:
- DB00898 DB01159
- Gene Ontology Go:
- Golgi apparatus
plasma membrane
voltage-gated potassium channel complex
G-protein activated inward rectifier potassium channel activity
inward rectifier potassium channel activity
potassium ion import
potassium ion transport
synaptic transmission - Gene Ontology Biological Process:
- potassium ion import
potassium ion transport
synaptic transmission - Gene Ontology Molecular Function:
- G-protein activated inward rectifier potassium channel activity
inward rectifier potassium channel activity - Gene Ontology Cellular Component:
- Golgi apparatus
plasma membrane
voltage-gated potassium channel complex - Keywords:
- Complete proteome
Congenital generalized lipodystrophy
Disease mutation
Ion channel
Ion transport
Membrane
Phosphoprotein
Potassium
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel