Names & Taxonomy
- Uniprot ID:
- P47985
- Entry Name:
- UCRI_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 1.10.2.2) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 11 (Complex III subunit IX) (Ubiquinol-cytochrome c reductase 8 kDa protein)]
- Gene Names:
- UQCRFS1
- Gene Names Primary:
- UQCRFS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 274
- Sequence:
- MLSVASRSGPFAPVLSATSRGVAGALRPLVQATVPATPEQPVLDLKRPFLSRESLSGQAVRRPLVASVGLNVPASVCYSHTDIKVPDFSEYRRLEVLDSTKSSRESSEARKGFSYLVTGVTTVGVAYAAKNAVTQFVSSMSASADVLALAKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTQKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRLGPAPLNLEVPTYEFTSDDMVIVG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane; Single-pass membrane protein.
Function
- Function:
- Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.; The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex.
- Catalytic Activity:
- Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H(+).
- Cofactor:
- COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49601;
- Gene Ontology Go:
- mitochondrial inner membrane
mitochondrial respiratory chain complex III
mitochondrion
myelin sheath
2 iron, 2 sulfur cluster binding
metal ion binding
ubiquinol-cytochrome-c reductase activity
cellular metabolic process
respiratory electron transport chain
response to antibiotic
response to drug
response to hormone
small molecule metabolic process - Gene Ontology Biological Process:
- cellular metabolic process
respiratory electron transport chain
response to antibiotic
response to drug
response to hormone
small molecule metabolic process - Gene Ontology Molecular Function:
- 2 iron, 2 sulfur cluster binding
metal ion binding
ubiquinol-cytochrome-c reductase activity - Gene Ontology Cellular Component:
- mitochondrial inner membrane
mitochondrial respiratory chain complex III
mitochondrion
myelin sheath - Keywords:
- 2Fe-2S
Complete proteome
Direct protein sequencing
Disulfide bond
Electron transport
Iron
Iron-sulfur
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Polymorphism
Reference proteome
Respiratory chain
Transit peptide
Transmembrane
Transmembrane helix
Transport