Names & Taxonomy

Uniprot ID:
P47901
Entry Name:
V1BR_HUMAN
Status:
reviewed
Protein Names:
Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor)
Gene Names:
AVPR1B AVPR3 VPR3
Gene Names Primary:
AVPR1B
Organism:
Homo sapiens (Human)

Structure

Length:
424
Sequence:
MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.
Cross Reference Drug Bank:
DB00035 DB02638 DB00067
Gene Ontology Go:
endosome
integral component of plasma membrane
plasma membrane
peptide binding
protein kinase C binding
vasopressin receptor activity
activation of phospholipase C activity
cellular response to hormone stimulus
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of vasoconstriction
regulation of systemic arterial blood pressure by vasopressin
response to peptide
Gene Ontology Biological Process:
activation of phospholipase C activity
cellular response to hormone stimulus
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of vasoconstriction
regulation of systemic arterial blood pressure by vasopressin
response to peptide
Gene Ontology Molecular Function:
peptide binding
protein kinase C binding
vasopressin receptor activity
Gene Ontology Cellular Component:
endosome
integral component of plasma membrane
plasma membrane
Keywords:
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
7929452 7805841 9357056 9581826 10607899 16710414 17909131