Names & Taxonomy
- Uniprot ID:
- P47901
- Entry Name:
- V1BR_HUMAN
- Status:
- reviewed
- Protein Names:
- Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor)
- Gene Names:
- AVPR1B AVPR3 VPR3
- Gene Names Primary:
- AVPR1B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 424
- Sequence:
- MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.
- Cross Reference Drug Bank:
- DB00035 DB02638 DB00067
- Gene Ontology Go:
- endosome
integral component of plasma membrane
plasma membrane
peptide binding
protein kinase C binding
vasopressin receptor activity
activation of phospholipase C activity
cellular response to hormone stimulus
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of vasoconstriction
regulation of systemic arterial blood pressure by vasopressin
response to peptide - Gene Ontology Biological Process:
- activation of phospholipase C activity
cellular response to hormone stimulus
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of vasoconstriction
regulation of systemic arterial blood pressure by vasopressin
response to peptide - Gene Ontology Molecular Function:
- peptide binding
protein kinase C binding
vasopressin receptor activity - Gene Ontology Cellular Component:
- endosome
integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix