Names & Taxonomy

Uniprot ID:
P47895
Entry Name:
AL1A3_HUMAN
Status:
reviewed
Protein Names:
Aldehyde dehydrogenase family 1 member A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3) (RalDH3)
Gene Names:
ALDH1A3 ALDH6
Gene Names Primary:
ALDH1A3
Organism:
Homo sapiens (Human)

Structure

Length:
512
Sequence:
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
Pathway:
Cofactor metabolism; retinol metabolism.
Catalytic Activity:
An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
Active Site:
ACT_SITE 280 280 Proton acceptor.
Cross Reference Drug Bank:
DB00162
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
aldehyde dehydrogenase (NAD) activity
aldehyde dehydrogenase activity
NAD+ binding
protein homodimerization activity
thyroid hormone binding
embryonic eye morphogenesis
face development
inner ear morphogenesis
locomotory behavior
neuromuscular process controlling balance
nucleus accumbens development
olfactory pit development
optic cup morphogenesis involved in camera-type eye development
positive regulation of apoptotic process
retinal metabolic process
retinoic acid biosynthetic process
retinoic acid metabolic process
retinol metabolic process
righting reflex
Gene Ontology Biological Process:
embryonic eye morphogenesis
face development
inner ear morphogenesis
locomotory behavior
neuromuscular process controlling balance
nucleus accumbens development
olfactory pit development
optic cup morphogenesis involved in camera-type eye development
positive regulation of apoptotic process
retinal metabolic process
retinoic acid biosynthetic process
retinoic acid metabolic process
retinol metabolic process
righting reflex
Gene Ontology Molecular Function:
aldehyde dehydrogenase (NAD) activity
aldehyde dehydrogenase activity
NAD+ binding
protein homodimerization activity
thyroid hormone binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
Keywords:
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Microphthalmia
NAD
Oxidoreductase
Polymorphism
Reference proteome

Publication

PubMed ID:
7698756 15489334 21269460 22814378 23591992 23312594 23646827 24568872 24024553 23881059 24777706