Names & Taxonomy
- Uniprot ID:
- P47895
- Entry Name:
- AL1A3_HUMAN
- Status:
- reviewed
- Protein Names:
- Aldehyde dehydrogenase family 1 member A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3) (RalDH3)
- Gene Names:
- ALDH1A3 ALDH6
- Gene Names Primary:
- ALDH1A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 512
- Sequence:
- MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
- Pathway:
- Cofactor metabolism; retinol metabolism.
- Catalytic Activity:
- An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
- Active Site:
- ACT_SITE 280 280 Proton acceptor.
- Cross Reference Drug Bank:
- DB00162
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
aldehyde dehydrogenase (NAD) activity
aldehyde dehydrogenase activity
NAD+ binding
protein homodimerization activity
thyroid hormone binding
embryonic eye morphogenesis
face development
inner ear morphogenesis
locomotory behavior
neuromuscular process controlling balance
nucleus accumbens development
olfactory pit development
optic cup morphogenesis involved in camera-type eye development
positive regulation of apoptotic process
retinal metabolic process
retinoic acid biosynthetic process
retinoic acid metabolic process
retinol metabolic process
righting reflex - Gene Ontology Biological Process:
- embryonic eye morphogenesis
face development
inner ear morphogenesis
locomotory behavior
neuromuscular process controlling balance
nucleus accumbens development
olfactory pit development
optic cup morphogenesis involved in camera-type eye development
positive regulation of apoptotic process
retinal metabolic process
retinoic acid biosynthetic process
retinoic acid metabolic process
retinol metabolic process
righting reflex - Gene Ontology Molecular Function:
- aldehyde dehydrogenase (NAD) activity
aldehyde dehydrogenase activity
NAD+ binding
protein homodimerization activity
thyroid hormone binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome - Keywords:
- Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Microphthalmia
NAD
Oxidoreductase
Polymorphism
Reference proteome