Names & Taxonomy

Uniprot ID:
P47871
Entry Name:
GLR_HUMAN
Status:
reviewed
Protein Names:
Glucagon receptor (GL-R)
Gene Names:
GCGR
Gene Names Primary:
GCGR
Organism:
Homo sapiens (Human)

Structure

Length:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
Cross Reference Drug Bank:
DB00040
Gene Ontology Go:
endosome
integral component of membrane
integral component of plasma membrane
plasma membrane
glucagon receptor activity
guanyl-nucleotide exchange factor activity
peptide hormone binding
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell surface receptor signaling pathway
cellular response to glucagon stimulus
energy reserve metabolic process
exocytosis
generation of precursor metabolites and energy
glucose homeostasis
hormone-mediated signaling pathway
positive regulation of GTPase activity
regulation of blood pressure
regulation of glycogen metabolic process
response to nutrient
response to starvation
small molecule metabolic process
Gene Ontology Biological Process:
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell surface receptor signaling pathway
cellular response to glucagon stimulus
energy reserve metabolic process
exocytosis
generation of precursor metabolites and energy
glucose homeostasis
hormone-mediated signaling pathway
positive regulation of GTPase activity
regulation of blood pressure
regulation of glycogen metabolic process
response to nutrient
response to starvation
small molecule metabolic process
Gene Ontology Molecular Function:
glucagon receptor activity
guanyl-nucleotide exchange factor activity
peptide hormone binding
Gene Ontology Cellular Component:
endosome
integral component of membrane
integral component of plasma membrane
plasma membrane
Keywords:
3D-structure
Cell membrane
Complete proteome
Diabetes mellitus
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
7507321 8144028 15489334 8020989 9287038 24275569 16221670 22908259 23863937 7589886 19657311