Names & Taxonomy

Uniprot ID:
P45844
Entry Name:
ABCG1_HUMAN
Status:
reviewed
Protein Names:
ATP-binding cassette sub-family G member 1 (ATP-binding cassette transporter 8) (White protein homolog)
Gene Names:
ABCG1 ABC8 WHT1
Gene Names Primary:
ABCG1
Organism:
Homo sapiens (Human)

Structure

Length:
678
Sequence:
MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.
Cross Reference Drug Bank:
DB00171
Gene Ontology Go:
endoplasmic reticulum membrane
endosome
external side of plasma membrane
Golgi apparatus
Golgi membrane
integral component of membrane
integral component of plasma membrane
intracellular membrane-bounded organelle
mitochondrion
nucleoplasm
plasma membrane
recycling endosome
ADP binding
ATP binding
cholesterol binding
cholesterol transporter activity
glycoprotein transporter activity
phospholipid binding
phospholipid transporter activity
protein dimerization activity
protein heterodimerization activity
protein homodimerization activity
sterol-transporting ATPase activity
toxin transporter activity
amyloid precursor protein catabolic process
cholesterol efflux
cholesterol homeostasis
cholesterol metabolic process
detection of hormone stimulus
glycoprotein transport
high-density lipoprotein particle remodeling
intracellular cholesterol transport
lipoprotein metabolic process
low-density lipoprotein particle remodeling
negative regulation of cholesterol storage
negative regulation of macrophage derived foam cell differentiation
phospholipid efflux
phospholipid homeostasis
positive regulation of cholesterol biosynthetic process
positive regulation of cholesterol efflux
regulation of cholesterol esterification
regulation of transcription, DNA-templated
response to high density lipoprotein particle
response to lipid
response to organic substance
reverse cholesterol transport
small molecule metabolic process
toxin transport
transmembrane transport
Gene Ontology Biological Process:
amyloid precursor protein catabolic process
cholesterol efflux
cholesterol homeostasis
cholesterol metabolic process
detection of hormone stimulus
glycoprotein transport
high-density lipoprotein particle remodeling
intracellular cholesterol transport
lipoprotein metabolic process
low-density lipoprotein particle remodeling
negative regulation of cholesterol storage
negative regulation of macrophage derived foam cell differentiation
phospholipid efflux
phospholipid homeostasis
positive regulation of cholesterol biosynthetic process
positive regulation of cholesterol efflux
regulation of cholesterol esterification
regulation of transcription, DNA-templated
response to high density lipoprotein particle
response to lipid
response to organic substance
reverse cholesterol transport
small molecule metabolic process
toxin transport
transmembrane transport
Gene Ontology Molecular Function:
ADP binding
ATP binding
cholesterol binding
cholesterol transporter activity
glycoprotein transporter activity
phospholipid binding
phospholipid transporter activity
protein dimerization activity
protein heterodimerization activity
protein homodimerization activity
sterol-transporting ATPase activity
toxin transporter activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
endosome
external side of plasma membrane
Golgi apparatus
Golgi membrane
integral component of membrane
integral component of plasma membrane
intracellular membrane-bounded organelle
mitochondrion
nucleoplasm
plasma membrane
recycling endosome
Keywords:
ATP-binding
Alternative splicing
Complete proteome
Endoplasmic reticulum
Golgi apparatus
Lipid transport
Lipoprotein
Membrane
Nucleotide-binding
Palmitate
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q9H172

Publication

PubMed ID:
8659545 10950923 11279031 11162488 11500512 10830953 15489334 9034316 10799558 10639163 12032171 11590207 11350058 22042635 23388354