Names & Taxonomy
- Uniprot ID:
- P45844
- Entry Name:
- ABCG1_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-binding cassette sub-family G member 1 (ATP-binding cassette transporter 8) (White protein homolog)
- Gene Names:
- ABCG1 ABC8 WHT1
- Gene Names Primary:
- ABCG1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 678
- Sequence:
- MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.
- Cross Reference Drug Bank:
- DB00171
- Gene Ontology Go:
- endoplasmic reticulum membrane
endosome
external side of plasma membrane
Golgi apparatus
Golgi membrane
integral component of membrane
integral component of plasma membrane
intracellular membrane-bounded organelle
mitochondrion
nucleoplasm
plasma membrane
recycling endosome
ADP binding
ATP binding
cholesterol binding
cholesterol transporter activity
glycoprotein transporter activity
phospholipid binding
phospholipid transporter activity
protein dimerization activity
protein heterodimerization activity
protein homodimerization activity
sterol-transporting ATPase activity
toxin transporter activity
amyloid precursor protein catabolic process
cholesterol efflux
cholesterol homeostasis
cholesterol metabolic process
detection of hormone stimulus
glycoprotein transport
high-density lipoprotein particle remodeling
intracellular cholesterol transport
lipoprotein metabolic process
low-density lipoprotein particle remodeling
negative regulation of cholesterol storage
negative regulation of macrophage derived foam cell differentiation
phospholipid efflux
phospholipid homeostasis
positive regulation of cholesterol biosynthetic process
positive regulation of cholesterol efflux
regulation of cholesterol esterification
regulation of transcription, DNA-templated
response to high density lipoprotein particle
response to lipid
response to organic substance
reverse cholesterol transport
small molecule metabolic process
toxin transport
transmembrane transport - Gene Ontology Biological Process:
- amyloid precursor protein catabolic process
cholesterol efflux
cholesterol homeostasis
cholesterol metabolic process
detection of hormone stimulus
glycoprotein transport
high-density lipoprotein particle remodeling
intracellular cholesterol transport
lipoprotein metabolic process
low-density lipoprotein particle remodeling
negative regulation of cholesterol storage
negative regulation of macrophage derived foam cell differentiation
phospholipid efflux
phospholipid homeostasis
positive regulation of cholesterol biosynthetic process
positive regulation of cholesterol efflux
regulation of cholesterol esterification
regulation of transcription, DNA-templated
response to high density lipoprotein particle
response to lipid
response to organic substance
reverse cholesterol transport
small molecule metabolic process
toxin transport
transmembrane transport - Gene Ontology Molecular Function:
- ADP binding
ATP binding
cholesterol binding
cholesterol transporter activity
glycoprotein transporter activity
phospholipid binding
phospholipid transporter activity
protein dimerization activity
protein heterodimerization activity
protein homodimerization activity
sterol-transporting ATPase activity
toxin transporter activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
endosome
external side of plasma membrane
Golgi apparatus
Golgi membrane
integral component of membrane
integral component of plasma membrane
intracellular membrane-bounded organelle
mitochondrion
nucleoplasm
plasma membrane
recycling endosome - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Endoplasmic reticulum
Golgi apparatus
Lipid transport
Lipoprotein
Membrane
Nucleotide-binding
Palmitate
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q9H172