Names & Taxonomy
- Uniprot ID:
- P43681
- Entry Name:
- ACHA4_HUMAN
- Status:
- reviewed
- Protein Names:
- Neuronal acetylcholine receptor subunit alpha-4
- Gene Names:
- CHRNA4 NACRA4
- Gene Names Primary:
- CHRNA4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 627
- Sequence:
- MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane
Function
- Function:
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
- Cross Reference Drug Bank:
- DB01351 DB01352 DB00237 DB00241 DB01353 DB09028 DB00514 DB00898 DB00674 DB01354 DB01355 DB00849 DB00184 DB00312 DB01174 DB00794 DB00418 DB00306 DB00599 DB01273
- Gene Ontology Go:
- acetylcholine-gated channel complex
cell junction
dendrite
external side of plasma membrane
integral component of membrane
membrane
neuronal cell body
plasma membrane
postsynaptic membrane
acetylcholine binding
acetylcholine receptor activity
acetylcholine-activated cation-selective channel activity
ligand-gated ion channel activity
action potential
B cell activation
behavioral response to nicotine
calcium ion transport
cation transmembrane transport
cognition
DNA repair
exploration behavior
inhibitory postsynaptic potential
ion transmembrane transport
ion transport
locomotory behavior
membrane depolarization
neurological system process
neuromuscular synaptic transmission
regulation of dopamine secretion
regulation of membrane potential
respiratory gaseous exchange
response to hypoxia
response to nicotine
response to oxidative stress
sensory perception of pain
signal transduction
synaptic transmission
synaptic transmission, cholinergic - Gene Ontology Biological Process:
- action potential
B cell activation
behavioral response to nicotine
calcium ion transport
cation transmembrane transport
cognition
DNA repair
exploration behavior
inhibitory postsynaptic potential
ion transmembrane transport
ion transport
locomotory behavior
membrane depolarization
neurological system process
neuromuscular synaptic transmission
regulation of dopamine secretion
regulation of membrane potential
respiratory gaseous exchange
response to hypoxia
response to nicotine
response to oxidative stress
sensory perception of pain
signal transduction
synaptic transmission
synaptic transmission, cholinergic - Gene Ontology Molecular Function:
- acetylcholine-activated cation-selective channel activity
acetylcholine binding
acetylcholine receptor activity
ligand-gated ion channel activity - Gene Ontology Cellular Component:
- acetylcholine-gated channel complex
cell junction
dendrite
external side of plasma membrane
integral component of membrane
membrane
neuronal cell body
plasma membrane
postsynaptic membrane - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Epilepsy
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport