Names & Taxonomy
- Uniprot ID:
- P43235
- Entry Name:
- CATK_HUMAN
- Status:
- reviewed
- Protein Names:
- Cathepsin K (EC 3.4.22.38) (Cathepsin O) (Cathepsin O2) (Cathepsin X)
- Gene Names:
- CTSK CTSO CTSO2
- Gene Names Primary:
- CTSK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 329
- Sequence:
- MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome.
Function
- Function:
- Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
- Catalytic Activity:
- Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
- Active Site:
- ACT_SITE 139 139
- Gene Ontology Go:
- endolysosome lumen
extracellular region
extracellular space
lysosome
collagen binding
cysteine-type endopeptidase activity
cysteine-type peptidase activity
fibronectin binding
proteoglycan binding
bone resorption
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
innate immune response
intramembranous ossification
positive regulation of protein targeting to mitochondrion
proteolysis
proteolysis involved in cellular protein catabolic process
regulation of mitophagy
toll-like receptor signaling pathway - Gene Ontology Biological Process:
- bone resorption
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
innate immune response
intramembranous ossification
positive regulation of protein targeting to mitochondrion
proteolysis
proteolysis involved in cellular protein catabolic process
regulation of mitophagy
toll-like receptor signaling pathway - Gene Ontology Molecular Function:
- collagen binding
cysteine-type endopeptidase activity
cysteine-type peptidase activity
fibronectin binding
proteoglycan binding - Gene Ontology Cellular Component:
- endolysosome lumen
extracellular region
extracellular space
lysosome - Keywords:
- 3D-structure
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Protease
Reference proteome
Signal
Thiol protease
Zymogen