Names & Taxonomy
- Uniprot ID:
- P43119
- Entry Name:
- PI2R_HUMAN
- Status:
- reviewed
- Protein Names:
- Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)
- Gene Names:
- PTGIR PRIPR
- Gene Names Primary:
- PTGIR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 386
- Sequence:
- MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
- Cross Reference Drug Bank:
- DB01160 DB01240 DB01088 DB11362 DB00374
- Gene Ontology Go:
- cytosol
integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
guanyl-nucleotide exchange factor activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
blood coagulation
cell-cell signaling
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of platelet-derived growth factor receptor signaling pathway
negative regulation of smooth muscle cell proliferation
positive regulation of cAMP biosynthetic process
positive regulation of cAMP-mediated signaling
positive regulation of GTPase activity
response to lipopolysaccharide - Gene Ontology Biological Process:
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
blood coagulation
cell-cell signaling
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of platelet-derived growth factor receptor signaling pathway
negative regulation of smooth muscle cell proliferation
positive regulation of cAMP biosynthetic process
positive regulation of cAMP-mediated signaling
positive regulation of GTPase activity
response to lipopolysaccharide - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
guanyl-nucleotide exchange factor activity - Gene Ontology Cellular Component:
- cytosol
integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Methylation
Palmitate
Polymorphism
Prenylation
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix