Names & Taxonomy
- Uniprot ID:
- P43115
- Entry Name:
- PE2R3_HUMAN
- Status:
- reviewed
- Protein Names:
- Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)
- Gene Names:
- PTGER3
- Gene Names Primary:
- PTGER3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 390
- Sequence:
- MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).
- Cross Reference Drug Bank:
- DB00905 DB00917 DB00929
- Gene Ontology Go:
- brush border membrane
cell surface
integral component of membrane
integral component of plasma membrane
neuronal cell body
nuclear envelope
nuclear membrane
plasma membrane
proximal neuron projection
prostaglandin E receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
cell death
cellular response to forskolin
cellular response to interleukin-1
cellular response to lipopolysaccharide
female pregnancy
G-protein coupled receptor signaling pathway
intestine smooth muscle contraction
intracellular receptor signaling pathway
maternal process involved in parturition
negative regulation of calcium ion transmembrane transport
negative regulation of cAMP biosynthetic process
negative regulation of circadian sleep/wake cycle, wakefulness
negative regulation of forebrain neuron differentiation
negative regulation of gastrin-induced gastric acid secretion
negative regulation of insulin secretion
negative regulation of norepinephrine secretion
negative regulation of platelet aggregation
negative regulation of potassium ion transmembrane transport
positive regulation of cAMP biosynthetic process
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of colon smooth muscle contraction
positive regulation of cytosolic calcium ion concentration
positive regulation of fever generation
positive regulation of gastric mucosal blood circulation
positive regulation of gene expression
positive regulation of inhibitory G-protein coupled receptor phosphorylation
positive regulation of myofibroblast contraction
positive regulation of neutrophil extravasation
positive regulation of smooth muscle contraction involved in micturition
positive regulation of vasoconstriction
prostaglandin receptor internalization
response to drug
response to estradiol
response to progesterone
response to salt
transcription, DNA-templated
urinary bladder smooth muscle contraction - Gene Ontology Biological Process:
- cell death
cellular response to forskolin
cellular response to interleukin-1
cellular response to lipopolysaccharide
female pregnancy
G-protein coupled receptor signaling pathway
intestine smooth muscle contraction
intracellular receptor signaling pathway
maternal process involved in parturition
negative regulation of calcium ion transmembrane transport
negative regulation of cAMP biosynthetic process
negative regulation of circadian sleep/wake cycle, wakefulness
negative regulation of forebrain neuron differentiation
negative regulation of gastrin-induced gastric acid secretion
negative regulation of insulin secretion
negative regulation of norepinephrine secretion
negative regulation of platelet aggregation
negative regulation of potassium ion transmembrane transport
positive regulation of cAMP biosynthetic process
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of colon smooth muscle contraction
positive regulation of cytosolic calcium ion concentration
positive regulation of fever generation
positive regulation of gastric mucosal blood circulation
positive regulation of gene expression
positive regulation of inhibitory G-protein coupled receptor phosphorylation
positive regulation of myofibroblast contraction
positive regulation of neutrophil extravasation
positive regulation of smooth muscle contraction involved in micturition
positive regulation of vasoconstriction
prostaglandin receptor internalization
response to drug
response to estradiol
response to progesterone
response to salt
transcription, DNA-templated
urinary bladder smooth muscle contraction - Gene Ontology Molecular Function:
- prostaglandin E receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding - Gene Ontology Cellular Component:
- brush border membrane
cell surface
integral component of membrane
integral component of plasma membrane
neuronal cell body
nuclear envelope
nuclear membrane
plasma membrane
proximal neuron projection - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix