Names & Taxonomy
- Uniprot ID:
- P43007
- Entry Name:
- SATT_HUMAN
- Status:
- reviewed
- Protein Names:
- Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (SATT) (Solute carrier family 1 member 4)
- Gene Names:
- SLC1A4 ASCT1 SATT
- Gene Names Primary:
- SLC1A4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 532
- Sequence:
- MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGAALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.
- Cross Reference Drug Bank:
- DB00160
- Gene Ontology Go:
- cell surface
centrosome
dendrite
extracellular exosome
integral component of membrane
integral component of plasma membrane
intermediate filament
melanosome
membrane
microtubule organizing center
neuronal cell body
plasma membrane
chloride channel activity
L-alanine transmembrane transporter activity
L-cystine transmembrane transporter activity
L-glutamine transmembrane transporter activity
L-hydroxyproline transmembrane transporter activity
L-proline transmembrane transporter activity
L-serine transmembrane transporter activity
L-threonine transmembrane transporter activity
sodium:dicarboxylate symporter activity
amino acid transport
chloride transmembrane transport
chloride transport
cognition
glutamine transport
hydroxyproline transport
ion transport
L-alanine transport
L-cystine transport
L-serine transport
mitophagy in response to mitochondrial depolarization
proline transmembrane transport
proline transport
synaptic transmission, glutamatergic
threonine transport
transmembrane transport - Gene Ontology Biological Process:
- amino acid transport
chloride transmembrane transport
chloride transport
cognition
glutamine transport
hydroxyproline transport
ion transport
L-alanine transport
L-cystine transport
L-serine transport
mitophagy in response to mitochondrial depolarization
proline transmembrane transport
proline transport
synaptic transmission, glutamatergic
threonine transport
transmembrane transport - Gene Ontology Molecular Function:
- chloride channel activity
L-alanine transmembrane transporter activity
L-cystine transmembrane transporter activity
L-glutamine transmembrane transporter activity
L-hydroxyproline transmembrane transporter activity
L-proline transmembrane transporter activity
L-serine transmembrane transporter activity
L-threonine transmembrane transporter activity
sodium:dicarboxylate symporter activity - Gene Ontology Cellular Component:
- cell surface
centrosome
dendrite
extracellular exosome
integral component of membrane
integral component of plasma membrane
intermediate filament
melanosome
membrane
microtubule organizing center
neuronal cell body
plasma membrane - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Disease mutation
Epilepsy
Glycoprotein
Membrane
Mental retardation
Phosphoprotein
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport