Names & Taxonomy
- Uniprot ID:
- P42702
- Entry Name:
- LIFR_HUMAN
- Status:
- reviewed
- Protein Names:
- Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118)
- Gene Names:
- LIFR
- Gene Names Primary:
- LIFR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1097
- Sequence:
- MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFTNFFQNKPND
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
Function
- Function:
- Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
- Gene Ontology Go:
- extracellular exosome
integral component of plasma membrane
plasma membrane
receptor complex
ciliary neurotrophic factor receptor binding
growth factor binding
leukemia inhibitory factor receptor activity
cell surface receptor signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
cytokine-mediated signaling pathway
leukemia inhibitory factor signaling pathway
negative regulation of muscle cell apoptotic process
neuron projection morphogenesis
oncostatin-M-mediated signaling pathway
organ regeneration
positive regulation of cell proliferation
response to cytokine
response to organic cyclic compound - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
cytokine-mediated signaling pathway
leukemia inhibitory factor signaling pathway
negative regulation of muscle cell apoptotic process
neuron projection morphogenesis
oncostatin-M-mediated signaling pathway
organ regeneration
positive regulation of cell proliferation
response to cytokine
response to organic cyclic compound - Gene Ontology Molecular Function:
- ciliary neurotrophic factor receptor binding
growth factor binding
leukemia inhibitory factor receptor activity - Gene Ontology Cellular Component:
- extracellular exosome
integral component of plasma membrane
plasma membrane
receptor complex - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Chromosomal rearrangement
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix