Names & Taxonomy
- Uniprot ID:
- P42357
- Entry Name:
- HUTH_HUMAN
- Status:
- reviewed
- Protein Names:
- Histidine ammonia-lyase (Histidase) (EC 4.3.1.3)
- Gene Names:
- HAL HIS
- Gene Names Primary:
- HAL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 657
- Sequence:
- MPRYTVHVRGEWLAVPCQDAQLTVGWLGREAVRRYIKNKPDNGGFTSVDDAHFLVRRCKGLGLLDNEDRLEVALENNEFVEVVIEGDAMSPDFIPSQPEGVYLYSKYREPEKYIELDGDRLTTEDLVNLGKGRYKIKLTPTAEKRVQKSREVIDSIIKEKTVVYGITTGFGKFARTVIPINKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIEMFNASCLPYVPEKGTVGASGDLAPLSHLALGLVGEGKMWSPKSGWADAKYVLEAHGLKPVILKPKEGLALINGTQMITSLGCEAVERASAIARQADIVAALTLEVLKGTTKAFDTDIHALRPHRGQIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKNIITTELNSATDNPMVFANRGETVSGGNFHGEYPAKALDYLAIGIHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLEQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLQFLHKKSTKIPESEDL
- Proteomes:
- UP000005640
Function
- Pathway:
- Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
- Catalytic Activity:
- L-histidine = urocanate + NH(3).
- Cross Reference Drug Bank:
- DB00117
- Gene Ontology Go:
- cytosol
histidine ammonia-lyase activity
cellular nitrogen compound metabolic process
histidine catabolic process
histidine catabolic process to glutamate and formamide
histidine catabolic process to glutamate and formate
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
histidine catabolic process
histidine catabolic process to glutamate and formamide
histidine catabolic process to glutamate and formate
small molecule metabolic process - Gene Ontology Molecular Function:
- histidine ammonia-lyase activity
- Gene Ontology Cellular Component:
- cytosol
- Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Histidine metabolism
Lyase
Phosphoprotein
Polymorphism
Reference proteome