Names & Taxonomy
- Uniprot ID:
- P42338
- Entry Name:
- PK3CB_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta)
- Gene Names:
- PIK3CB PIK3C1
- Gene Names Primary:
- PIK3CB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1070
- Sequence:
- MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.
- Pathway:
- Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.
- Catalytic Activity:
- ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
- Cross Reference Drug Bank:
- DB00201
- Gene Ontology Go:
- cytosol
intercellular bridge
nucleolus
nucleus
phosphatidylinositol 3-kinase complex
plasma membrane
1-phosphatidylinositol-3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
ATP binding
phosphatidylinositol 3-kinase activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
activation of MAPK activity
adaptive immune response
angiogenesis involved in wound healing
autophagy
blood coagulation
cell chemotaxis
cell migration
cellular calcium ion homeostasis
chemotaxis
embryonic cleavage
endothelial cell proliferation
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
homophilic cell adhesion via plasma membrane adhesion molecules
inflammatory response
innate immune response
insulin receptor signaling pathway
leukocyte migration
neurotrophin TRK receptor signaling pathway
phosphatidylinositol 3-kinase signaling
phosphatidylinositol biosynthetic process
phosphatidylinositol-mediated signaling
phospholipid metabolic process
platelet activation
platelet aggregation
positive regulation of autophagy
positive regulation of gene expression
protein phosphorylation
regulation of cell-matrix adhesion
regulation of clathrin-mediated endocytosis
signal transduction
small molecule metabolic process
T cell receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPK activity
adaptive immune response
angiogenesis involved in wound healing
autophagy
blood coagulation
cell chemotaxis
cell migration
cellular calcium ion homeostasis
chemotaxis
embryonic cleavage
endothelial cell proliferation
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
homophilic cell adhesion via plasma membrane adhesion molecules
inflammatory response
innate immune response
insulin receptor signaling pathway
leukocyte migration
neurotrophin TRK receptor signaling pathway
phosphatidylinositol 3-kinase signaling
phosphatidylinositol biosynthetic process
phosphatidylinositol-mediated signaling
phospholipid metabolic process
platelet activation
platelet aggregation
positive regulation of autophagy
positive regulation of gene expression
protein phosphorylation
regulation of cell-matrix adhesion
regulation of clathrin-mediated endocytosis
signal transduction
small molecule metabolic process
T cell receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- 1-phosphatidylinositol-3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
ATP binding
phosphatidylinositol 3-kinase activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity - Gene Ontology Cellular Component:
- cytosol
intercellular bridge
nucleolus
nucleus
phosphatidylinositol 3-kinase complex
plasma membrane - Keywords:
- ATP-binding
Autophagy
Cell adhesion
Complete proteome
Cytoplasm
Endocytosis
Kinase
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transferase - Interacts With:
- P08631; P27986; O00459