Names & Taxonomy
- Uniprot ID:
- P42263
- Entry Name:
- GRIA3_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3)
- Gene Names:
- GRIA3 GLUR3 GLURC
- Gene Names Primary:
- GRIA3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 894
- Sequence:
- MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression.
- Intramembrane:
- INTRAMEM 603 618 Helical; Pore-forming.
Function
- Function:
- Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
- Cross Reference Drug Bank:
- DB00898 DB01356
- Gene Ontology Go:
- AMPA glutamate receptor complex
asymmetric synapse
cell junction
dendritic shaft
dendritic spine
endocytic vesicle membrane
nucleoplasm
perikaryon
plasma membrane
postsynaptic density
postsynaptic membrane
synaptic cleft
terminal bouton
AMPA glutamate receptor activity
extracellular-glutamate-gated ion channel activity
glutamate receptor signaling pathway
response to fungicide
synaptic transmission
transport - Gene Ontology Biological Process:
- glutamate receptor signaling pathway
response to fungicide
synaptic transmission
transport - Gene Ontology Molecular Function:
- AMPA glutamate receptor activity
extracellular-glutamate-gated ion channel activity - Gene Ontology Cellular Component:
- AMPA glutamate receptor complex
asymmetric synapse
cell junction
dendritic shaft
dendritic spine
endocytic vesicle membrane
nucleoplasm
perikaryon
plasma membrane
postsynaptic density
postsynaptic membrane
synaptic cleft
terminal bouton - Keywords:
- Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Lipoprotein
Membrane
Mental retardation
Palmitate
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport