Names & Taxonomy
- Uniprot ID:
- P42081
- Entry Name:
- CD86_HUMAN
- Status:
- reviewed
- Protein Names:
- T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86)
- Gene Names:
- CD86 CD28LG2
- Gene Names Primary:
- CD86
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 329
- Sequence:
- MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREKIHIPERSDEAQRVFKSSKTSSCDKSDTCF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein.
Function
- Function:
- Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.; (Microbial infection) Acts as a receptor for adenovirus subgroup B.
- Cross Reference Drug Bank:
- DB01281 DB00098 DB06681
- Gene Ontology Go:
- cell surface
external side of plasma membrane
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
plasma membrane
coreceptor activity
receptor activity
virus receptor activity
adaptive immune response
aging
B cell activation
cell-cell signaling
cellular response to cytokine stimulus
cellular response to lipopolysaccharide
cellular response to metal ion
defense response to virus
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
immune response
innate immune response
myeloid dendritic cell differentiation
negative regulation of T cell anergy
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of activated T cell proliferation
positive regulation of cell proliferation
positive regulation of interleukin-2 biosynthetic process
positive regulation of interleukin-4 biosynthetic process
positive regulation of lymphotoxin A biosynthetic process
positive regulation of T-helper 2 cell differentiation
positive regulation of transcription, DNA-templated
response to drug
response to interferon-gamma
response to yeast
T cell activation
T cell costimulation
T cell proliferation involved in immune response
toll-like receptor 3 signaling pathway - Gene Ontology Biological Process:
- adaptive immune response
aging
B cell activation
cell-cell signaling
cellular response to cytokine stimulus
cellular response to lipopolysaccharide
cellular response to metal ion
defense response to virus
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
immune response
innate immune response
myeloid dendritic cell differentiation
negative regulation of T cell anergy
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of activated T cell proliferation
positive regulation of cell proliferation
positive regulation of interleukin-2 biosynthetic process
positive regulation of interleukin-4 biosynthetic process
positive regulation of lymphotoxin A biosynthetic process
positive regulation of T-helper 2 cell differentiation
positive regulation of transcription, DNA-templated
response to drug
response to interferon-gamma
response to yeast
T cell activation
T cell costimulation
T cell proliferation involved in immune response
toll-like receptor 3 signaling pathway - Gene Ontology Molecular Function:
- coreceptor activity
receptor activity
virus receptor activity - Gene Ontology Cellular Component:
- cell surface
external side of plasma membrane
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
plasma membrane - Keywords:
- 3D-structure
Adaptive immunity
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Immunity
Immunoglobulin domain
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
Ubl conjugation - Interacts With:
- P16410