Names & Taxonomy
- Uniprot ID:
- P41440
- Entry Name:
- S19A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Folate transporter 1 (FOLT) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (Solute carrier family 19 member 1)
- Gene Names:
- SLC19A1 FLOT1 RFC1
- Gene Names Primary:
- SLC19A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 591
- Sequence:
- MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGHALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump.
- Cross Reference Drug Bank:
- DB00563 DB06813
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
brush border membrane
integral component of plasma membrane
plasma membrane
folic acid binding
folic acid transporter activity
methotrexate transporter activity
reduced folate carrier activity
female pregnancy
folic acid metabolic process
folic acid transport
reduced folate transmembrane transport
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- female pregnancy
folic acid metabolic process
folic acid transport
reduced folate transmembrane transport
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- folic acid binding
folic acid transporter activity
methotrexate transporter activity
reduced folate carrier activity - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
brush border membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Folate-binding
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport