Names & Taxonomy
- Uniprot ID:
- P41240
- Entry Name:
- CSK_HUMAN
- Status:
- reviewed
- Protein Names:
- Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
- Gene Names:
- CSK
- Gene Names Primary:
- CSK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 450
- Sequence:
- MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 314 314 Proton acceptor.
- Gene Ontology Go:
- cell-cell junction
cytoplasm
cytosol
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
membrane raft
plasma membrane
ATP binding
identical protein binding
metal ion binding
non-membrane spanning protein tyrosine kinase activity
protein C-terminus binding
protein kinase A catalytic subunit binding
protein tyrosine kinase activity
receptor binding
adaptive immune response
adherens junction organization
blood coagulation
brain development
cell differentiation
cell migration
cellular response to peptide hormone stimulus
epidermal growth factor receptor signaling pathway
innate immune response
negative regulation of bone resorption
negative regulation of cell proliferation
negative regulation of ERK1 and ERK2 cascade
negative regulation of Golgi to plasma membrane protein transport
negative regulation of interleukin-6 production
negative regulation of kinase activity
negative regulation of low-density lipoprotein particle clearance
negative regulation of phagocytosis
oligodendrocyte differentiation
peptidyl-tyrosine autophosphorylation
platelet activation
positive regulation of MAP kinase activity
protein phosphorylation
regulation of cell proliferation
regulation of cytokine production
regulation of Fc receptor mediated stimulatory signaling pathway
T cell costimulation
T cell receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Biological Process:
- adaptive immune response
adherens junction organization
blood coagulation
brain development
cell differentiation
cell migration
cellular response to peptide hormone stimulus
epidermal growth factor receptor signaling pathway
innate immune response
negative regulation of bone resorption
negative regulation of cell proliferation
negative regulation of ERK1 and ERK2 cascade
negative regulation of Golgi to plasma membrane protein transport
negative regulation of interleukin-6 production
negative regulation of kinase activity
negative regulation of low-density lipoprotein particle clearance
negative regulation of phagocytosis
oligodendrocyte differentiation
peptidyl-tyrosine autophosphorylation
platelet activation
positive regulation of MAP kinase activity
protein phosphorylation
regulation of cell proliferation
regulation of cytokine production
regulation of Fc receptor mediated stimulatory signaling pathway
T cell costimulation
T cell receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Molecular Function:
- ATP binding
identical protein binding
metal ion binding
non-membrane spanning protein tyrosine kinase activity
protein C-terminus binding
protein kinase A catalytic subunit binding
protein tyrosine kinase activity
receptor binding - Gene Ontology Cellular Component:
- cell-cell junction
cytoplasm
cytosol
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
membrane raft
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Acetylation
Adaptive immunity
Cell membrane
Complete proteome
Cytoplasm
Immunity
Kinase
Magnesium
Manganese
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
SH2 domain
SH3 domain
Transferase
Tyrosine-protein kinase - Interacts With:
- Itself; P08069; Q9NWQ8; P08575; P49023; P00523