Names & Taxonomy
- Uniprot ID:
- P41143
- Entry Name:
- OPRD_HUMAN
- Status:
- reviewed
- Protein Names:
- Delta-type opioid receptor (D-OR-1) (DOR-1)
- Gene Names:
- OPRD1 OPRD
- Gene Names Primary:
- OPRD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 372
- Sequence:
- MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
- Cross Reference Drug Bank:
- DB06274 DB00321 DB00921 DB00611 DB00318 DB00514 DB00647 DB01081 DB09272 DB00813 DB01452 DB00956 DB00327 DB01221 DB06738 DB00854 DB00836 DB00333 DB00295 DB00844 DB01183 DB00704 DB00497 DB01192 DB00899 DB00708 DB06204 DB00193
- Gene Ontology Go:
- axon terminus
cytoplasm
dendrite membrane
integral component of plasma membrane
intrinsic component of plasma membrane
membrane raft
neuron projection
plasma membrane
postsynaptic membrane
vesicle
enkephalin receptor activity
neuropeptide binding
opioid receptor activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adult locomotory behavior
cellular response to growth factor stimulus
cellular response to hypoxia
cellular response to toxic substance
eating behavior
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
immune response
negative regulation of gene expression
negative regulation of protein oligomerization
neuropeptide signaling pathway
opioid receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of CREB transcription factor activity
positive regulation of peptidyl-serine phosphorylation
protein import into nucleus, translocation
regulation of calcium ion transport
regulation of mitochondrial membrane potential
regulation of sensory perception of pain
synaptic transmission - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adult locomotory behavior
cellular response to growth factor stimulus
cellular response to hypoxia
cellular response to toxic substance
eating behavior
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
immune response
negative regulation of gene expression
negative regulation of protein oligomerization
neuropeptide signaling pathway
opioid receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of CREB transcription factor activity
positive regulation of peptidyl-serine phosphorylation
protein import into nucleus, translocation
regulation of calcium ion transport
regulation of mitochondrial membrane potential
regulation of sensory perception of pain
synaptic transmission - Gene Ontology Molecular Function:
- enkephalin receptor activity
neuropeptide binding
opioid receptor activity - Gene Ontology Cellular Component:
- axon terminus
cytoplasm
dendrite membrane
integral component of plasma membrane
intrinsic component of plasma membrane
membrane raft
neuron projection
plasma membrane
postsynaptic membrane
vesicle - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix
Ubl conjugation - Interacts With:
- P11607; P16615; P27824; Q5JY77