Names & Taxonomy
- Uniprot ID:
- P40879
- Entry Name:
- S26A3_HUMAN
- Status:
- reviewed
- Protein Names:
- Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3)
- Gene Names:
- SLC26A3 DRA
- Gene Names Primary:
- SLC26A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 764
- Sequence:
- MIEPFGNQYIVARPVYSTNAFEENHKKTGRHHKTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISVGPFPILSMMVGLAVSGAVSKAVPDRNATTLGLPNNSNNSSLLDDERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTALIVLLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVSYGCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRILRKRNKALRKIRKLQKQGLLQVTPKGFICTVDTIKDSDEELDNNQIEVLDQPINTTDLPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHILMKKDYSTSKFNPSQEKDGKIDFTINTNGGLRNRVYEVPVETKF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
Function
- Function:
- Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
- Gene Ontology Go:
- apical plasma membrane
brush border membrane
integral component of plasma membrane
membrane
plasma membrane
sperm midpiece
anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
chloride transmembrane transporter activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity
transcription cofactor activity
transcription factor activity, sequence-specific DNA binding
transporter activity
anion transport
bicarbonate transport
cellular response to cAMP
chloride transmembrane transport
excretion
intracellular pH elevation
ion transport
membrane hyperpolarization
oxalate transport
regulation of intracellular pH
regulation of membrane potential
regulation of nucleic acid-templated transcription
regulation of transcription, DNA-templated
sperm capacitation
sulfate transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- anion transport
bicarbonate transport
cellular response to cAMP
chloride transmembrane transport
excretion
intracellular pH elevation
ion transport
membrane hyperpolarization
oxalate transport
regulation of intracellular pH
regulation of membrane potential
regulation of nucleic acid-templated transcription
regulation of transcription, DNA-templated
sperm capacitation
sulfate transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
chloride transmembrane transporter activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity
transcription cofactor activity
transcription factor activity, sequence-specific DNA binding
transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
brush border membrane
integral component of plasma membrane
membrane
plasma membrane
sperm midpiece - Keywords:
- Antiport
Cell membrane
Chloride
Complete proteome
Disease mutation
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q15599