Names & Taxonomy
- Uniprot ID:
- P40429
- Entry Name:
- RL13A_HUMAN
- Status:
- reviewed
- Protein Names:
- 60S ribosomal protein L13a (23 kDa highly basic protein)
- Gene Names:
- RPL13A
- Gene Names Primary:
- RPL13A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 203
- Sequence:
- MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLMRLRKQAEKNVEKKIDKYTEVLKTHGLLV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
- Gene Ontology Go:
- cytoplasm
cytosol
cytosolic large ribosomal subunit
focal adhesion
GAIT complex
intracellular ribonucleoprotein complex
large ribosomal subunit
membrane
nucleolus
nucleus
mRNA binding
poly(A) RNA binding
structural constituent of ribosome
cellular nitrogen compound metabolic process
cellular protein metabolic process
cellular response to interferon-gamma
gene expression
negative regulation of formation of translation preinitiation complex
negative regulation of translation
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
selenium compound metabolic process
selenocysteine metabolic process
small molecule metabolic process
SRP-dependent cotranslational protein targeting to membrane
translation
translational elongation
translational initiation
translational termination
viral life cycle
viral process
viral transcription - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
cellular protein metabolic process
cellular response to interferon-gamma
gene expression
negative regulation of formation of translation preinitiation complex
negative regulation of translation
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
selenium compound metabolic process
selenocysteine metabolic process
small molecule metabolic process
SRP-dependent cotranslational protein targeting to membrane
translation
translational elongation
translational initiation
translational termination
viral life cycle
viral process
viral transcription - Gene Ontology Molecular Function:
- mRNA binding
poly(A) RNA binding
structural constituent of ribosome - Gene Ontology Cellular Component:
- cytoplasm
cytosol
cytosolic large ribosomal subunit
focal adhesion
GAIT complex
intracellular ribonucleoprotein complex
large ribosomal subunit
membrane
nucleolus
nucleus - Keywords:
- 3D-structure
Acetylation
Citrullination
Complete proteome
Cytoplasm
Direct protein sequencing
Phosphoprotein
Reference proteome
Ribonucleoprotein
Ribosomal protein
Translation regulation